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Volume 16, Number 8—August 2010

CME ACTIVITY - Research

Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children

Chung-Chen Li1, Lin Wang1, Hock-Liew Eng1, Huey-Ling You, Ling-Sai Chang, Kuo-Shu Tang, Ying-Jui Lin, Hsuan-Chang Kuo, Ing-Kit Lee, Jien-Wei Liu, Eng-Yen Huang, and Kuender D. YangComments to Author 
Author affiliations: Chang Gung Memorial Hospital–Kaohsiung Medical Center, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung

Main Article

Table 3

Characteristics of 60 patients who were infected with pandemic (H1N1) 2009 virus, by age group, Taiwan*

Characteristic No. (%) patients
p value†
Age <13 years, n = 31 Age >13 years, n = 29
Sex, M/F
14/17
15/14
0.611
Disease severity
URI/bronchitis 22 (71.0) 22 (75.9) 0.859‡
Pneumonia 9 (29.0) 5 (17.2)
Meningoencephalitis
0
2 (6.9)
Duration of fever after antiviral treatment, h
<24 23 (74.2) 26 (89.7) 0.122§
24–48 5 (16.1) 2 (6.9)
>48
3 (9.7)
1 (3.4)
Time to initiate antiviral treatment, h
<48 25 (80.6) 24 (82.8) 0.833
>48
6 (19.4)
5 (17.2)
Viral load from the first throat swab, log10 copies/mL
<4.35 16 (51.6) 14 (48.3) 0.796
>4.35
15 (48.4)
15 (51.7)
Coexisting condition
Any 1 condition 8 (25.8) 6 (20.7) 0.640
Asthma 7 0
Ventricular septal defect 1 0
Hypertension 0 5
Cerebrovascular disease 0 1
Congestive heart failure 0 1
Diabetes 0 1
Pregnancy 0 1

*URI, upper respiratory tract infection.
†p values were calculated by χ2 test.
‡The URI/bronchitis group was compared with the combined group of pneumonia and meningoencephalitis.
§Fever lasting <24 h after antiviral treatment vs. fever lasting 24 h or longer after antiviral treatment.

Main Article

1These authors contributed equally to this article.

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