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Volume 16, Number 9—September 2010

Research

Trends in Hospitalizations for Peptic Ulcer Disease, United States, 1998–20051

Lydia B. Feinstein2, Robert C. Holman, Krista L. Yorita Christensen, Claudia A. Steiner, and David L. SwerdlowComments to Author 
Author affiliations: Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (L.B. Feinstein, R.C. Holman, K.L. Yorita Christensen, D.L. Swerdlow); Agency for Healthcare Research and Quality, Rockville, Maryland, USA (C.A. Steiner)

Main Article

Table 2

Number of hospitalizations and the age-adjusted and age-specific hospitalization rates for first-listed discharge diagnoses of peptic ulcer disease, United States, 1998–2005*

Characteristic 1998
2005
% Rate change β-coefficient‡
No. (SE) Rate† (95% CI) No. (SE) Rate† (95% CI)
Age, y
<20 1,524 (133) 1.9 (1.6–2.2) 1,924 (290) 2.4 (1.7–3.0) +26 0.016§
20–44 26,420 (817) 25.5 (23.9–27.0) 21,523 (656) 20.5 (19.3–21.7) −20 −0.648¶
45–64 50,446 (1,164) 86.6 (82.7–90.5) 50,993 (1,326) 70.0 (66.4–73.6) −19 −1.911¶
≥6>65
115,181 (2,750)
332.7 (317.1–348.3)

95,349 (2,449)
259.2 (246.1–272.2)
−22
−8.759¶
Sex
M 100,721 (2,159) 83.1 (80.4–85.6) 84,883 (2,013) 62.2 (59.9–64.4) −25 −2.164¶
F
92,831 (2,080)
60.8 (58.7–62.9)

84,808 (2,040)
51.3 (49.5–53.2)
−16
−0.886¶
Race/ethnicity#
White 111,092 (4,086) 50.3 (47.7–52.9) 91,939 (3,765) 39.5 (37.3–41.8) −22 −1.696¶
Black 18,188 (1,428) 68.6 (61.7–75.6) 12,794 (899) 41.4 (37.5–45.4) −40 −2.093¶
Hispanic 10,850 (1,310) 63.3 (50.7–75.9) 11,079 (1,034) 43.4 (37.3–49.6) −31 0.308§
Asian/Pacific Islander
4,526 (673)
59.7 (45.4–73.9)

4,220 (520)
38.2 (30.9–45.4)
−36
−1.620**
Region
Northeast 33,578 (1,746) 60.1 (55.5–64.7) 29,046 (1,740) 49.3 (45.1–53.6) −18 −1.697¶
Midwest 44,910 (1,909) 70.1 (65.5–74.7) 39,097 (1,562) 57.5 (53.8–61.1) −18 −0.964**
South 76,773 (2,551) 79.5 (75.6–83.4) 66,969 (2,711) 61.3 (57.8–64.8) −23 −2.046¶
West
38,315 (1,707)
68.9 (64.2–73.7)

34,746 (1,519)
53.8 (50.2–57.3)
−22
−1.129††
Total 193,576 (4,014) 71.1 (68.9–73.4) 169,858 (3,889) 56.5 (54.6–58.3) −21 −1.501¶

*Diagnosis codes 531–534 from the International Classification of Diseases, 9th Revision, Clinical Modification. National estimates were determined by using the Nationwide Inpatient Sample (21).
†Per 100,000 population.
‡β-coefficient from linear regression analysis, using a weighted least-squares technique, of the annual rate over the years of the study period. The p value corresponds to the test of the null hypothesis that the coefficient for year is zero.
§ p>0.05.
¶p<0.001.
#Race/ethnicity was missing for 26.0% of the hospitalizations. Data were insufficient for the race/ethnicity category American Indian/Alaska Native.
**0.01<p<0.05.
††0.001<p<0.01.

Main Article

1Presented in part at the Annual Interscience Conference on Antimicrobial Agents and Chemotherapy and Infectious Diseases Society of America; 2008 Oct 28; Washington, DC (abstract number L-4129).

2Current affiliation: University of North Carolina, Chapel Hill, North Carolina, USA.

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