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Volume 16, Number 9—September 2010

Research

Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene1

Gaëlle Cuzon, Thierry NaasComments to Author , HaVy Truong, Maria-Virginia Villegas, Karin T. Wisell, Yehuda Carmeli, Ana. C. Gales, Shiri Navon-Venezia, John P. Quinn, and Patrice Nordmann
Author affiliations: Author affiliations: Institut National de la Santé et de la Recherche Médicale, Paris, France (G. Cuzon, T. Naas, H. Truong, P. Nordmann); International Center for Medical Research and Training, Cali, Colombia (M.V. Villegas); Swedish Institute for Infectious Disease Control, Stockholm, Sweden (K.T. Wisell); Sourasky Medical Center, Tel Aviv, Israel (Y. Carmeli, S. Navon-Venezia); Universidade Federal de São Paulo, São Paulo, Brazil (A.C. Gales); John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, USA (J.P. Quinn); Chicago Infectious Disease Research Institute, Chicago (J.P. Quinn)

Main Article

Table 1

Geographic origin and structure of Tn4401 and other β-lactamases of Klebsiella pneumoniae isolates*

Isolate no. Isolate type Origin PCR result
KPC-2 Tn4401
Other β-lactamases
TnpA ISKPN7 ISKPN6 Deletion, bp SHV TEM CTX-M OXA
1 YC USA + + + + –100 SHV-11 TEM-1 OXA-9
2 GR Greece + + + + –100 SHV-11 TEM-1 OXA-9
3 K271 Sweden + + + + –100 SHV-11 TEM-1 OXA-9
4 KN2303 Colombia + + + + None SHV-11
5 KN633 Colombia + + + + None OKP-A TEM-1 CTX-M-12
6 INC H1521-6 Colombia + + + + None SHV-1 TEM-1 CTX-M-15
7 INC H1516-6 Colombia + + + + None SHV-1 TEM-1 CTX-M-15
8 HPTU 27635 Colombia + + + + None OKP-B
9 HPTU 2020532 Colombia + + + + None OKP-A TEM-1 CTX-M-12
10 A28006 Brazil + + + + None SHV-11 TEM-1 CTX-M-2
11 A28008 Brazil + + + + None SHV-11 TEM-1 CTX-M-2
12 A28009 Brazil + + + + None SHV-11 TEM-1 CTX-M-2
13 A28011 Brazil + + + + None SHV-11 TEM-1 CTX-M-2 OXA-9
14 A33504 Brazil + + + + None SHV-11 TEM-1 CTX-M-2 OXA-9
15 475 Israel + + + + –200 SHV-11 CTX-M-15
16 588 Israel + + + + –200 SHV-11 TEM-1 OXA-9

*KPC, K. pneumoniae carbapenemase.

Main Article

1This study was presented in part at the Interscience Conference on Antimicrobial Agents and Chemotherapy; 2009 Sep 12–15; San Francisco, CA, USA.

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