Recurrent Granulibacter bethesdensis Infections and Chronic Granulomatous Disease
Figure 4. Physical gene representation of DNA hybridization of 11 isolates of Granulibacter bethesdensis by DNA–DNA hybridization microarray-based investigation of gene distributions among G. bethesdensis isolates. Every open reading frame in the G. bethesdensis type strain is represented. Hybridization is shown in yellow, and absence of hybridization is shown in blue. Four sequential isolates (NIH 1.1, NIH 1.2, NIH 1.3, and NIH 1.4) from patient 1 are shown from left to right and group with an identical hybridization pattern. Three sequential isolates (NIH 2.1, NIH 2.2, and NIH 2.3) from patient 2 are shown from left to right and demonstrate virtually identical patterns of hybridization. Two isolates (NIH 3.1 and NIH 3.2) from patient 3 have different hybridization patterns. One isolate (NIH 4.1) from patient 4 has a unique hybridization pattern. One isolate (NIH 5.1) from patient 5 is distinct from that of his brother (patient 2). Dates that each infected tissue sample were obtained are listed. NIH, National Institutes of Health.