Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru
Olivier Cassar1, Marie-Lise Blondot1, Salim Mohanna, Gregory Jouvion, Francisco Bravo, Vicente Maco, Renan Duprez, Michel Huerre, Eduardo Gotuzzo, and Antoine Gessain
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (O. Cassar, M.-L. Blondot, G. Jouvion, R. Duprez, M. Huerre, A. Gessain); Centre National de la Recherche Scientifique, Paris (O. Cassar, M.-L. Blondot, R. Duprez, A. Gessain); Universidad Peruana Cayetano Heredia, Lima, Peru (S. Mohanna, F. Bravo, V. Maco, E. Gotuzzo)
Figure 1. Histologic patterns of cutaneous Kaposi sarcoma (KS) associated with a human herpesvirus 8 (HHV-8) type E infection. Patient 1: A) The spindle cells were organized as bundles, forming vascular slit-like spaces containing erythrocytes. Some macrophages containing hemosiderin were observed (data not shown). Scale bar = 25 μm. C) Immunohistochemical testing showed a positive signal for HHV-8 infection (latent nuclear antigen [LANA-1]) and CD34 (data not shown). The Perls staining also gave highly positive results (data not shown). Scale bar = 50 μm. (Patient 1 corresponds to the first patient [04/0480] in the Table A1], a 51-year-old mestizo man who had HIV-1 infection.) Patient 2: B) Spindle cells forming rare vascular channels, with numerous lymphocytes, plasma cells, and macrophages. Scale bar = 25 μm. D) Immunohistochemistry showed a lower positive signal for HHV-8 infection (LANA-1) and CD34 (data not shown). Few cells displayed a positive Perls staining (data not shown). Scale bar = 50 μm. (Patient 2 corresponds to the tenth patient [06/0772] in the online Table A1, a 24-year-old mestizo man with HIV-1 infection).
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