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Volume 17, Number 1—January 2011

Dispatch

Serologic Status for Pandemic (H1N1) 2009 Virus, Taiwan

Daniel Tsung-Ning Huang1, Pei-Lan Shao1, Kuo-Chin Huang, Chun-Yi Lu, Jen-Ren Wang, Shin-Ru Shih, Hsin Chi, Mei-Ru Lai, Chin-Yun Lee, Luan-Yin Chang, and Li-Min HuangComments to Author 
Author affiliations: Author affiliations: Mackay Memorial Hospital, Taipei, Taiwan (D.T.-N. Huang, H. Chi); National Taiwan University Hospital, Taipei (P.-L. Shao, K.-C. Huang, C.-Y. Lu, M.-R. Lai, C.-Y. Lee, L.-Y. Chang, L.-M. Huang); National Cheng Kung University, Tainan, Taiwan (J.-R. Wang); Chang-Gung Memorial Hospital, Taipei (S.-R. Shih); National Taiwan University, Taipei (L.-M. Huang)

Main Article

Table

Geometric mean titers of antibodies and rates of seroprotection against pandemic (H1N1) 2009 virus before and after seasonal influenza vaccination, by age, Taiwan, 2007–2008*

Group, age, y
Prevaccination GMT (95% CI)
Prevaccination seroprotection rate, %
Postvaccination GMT (95% CI)
Postvaccination seroprotection rate, %
p value
Children <5, n = 40)
HI
10.4 (9.9–10.9)
0
ND
ND
ND
Adults 20–49, n = 36
HI 12.1 (10.7–13.7) 2.8 12.1 (10.7–13.7) 2.80 NS
MN
26.3 (20.9–32.8)
0
31.7 (25.0–40.3)
0
<0.05
Older adults 50–74, n = 50
HI 16.7 (14.2–19.7) 16 16.7 (14.2–19.7) 16 NS
MN
59.0 (47.7–72.8)
20
74.6 (60.0–92.9)
32
<0.05
Elderly adults >75, n = 50
HI 22.7 (19.5–26.4) 36 23.3 (19.8–27.4) 38 0.159
MN
85.7 (70.8–103.9)
32
107 (89.2–128.5)
44
<0.05
*GMT, geometric mean titer; CI, confidence interval; HI, hemagglutination inhibition; ND, not done; NS, not significant. MN, microneutralization. Mean ± SD ages for the 4 groups were 20.0 ± 11.3 mo for children, 34.5 ± 7.5 y for adults, 65 ± 6 y for older adults, and 79 ± 3.3 y for elderly adults.

Main Article

1These authors contributed equally to this article.

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