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Volume 17, Number 1—January 2011

Letter

Class D OXA-48 Carbapenemase in Multidrug-Resistant Enterobacteria, Senegal

Olivier MoquetComments to Author , Coralie Bouchiat, Alfred Kinana, Abdoulaye Seck, Omar Arouna, Raymond Bercion, Sebastien Breurec, and Benoit Garin
Author affiliations: Author affiliations: Institut Pasteur, Dakar, Senegal (O. Moquet, C. Bouchiat, A. Kinana, A. Seck, S. Breurec, B. Garin); Hopital Principal, Dakar (O. Arouna, R. Bercion)

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Table

Resistance genes and carbapenem MICs of 11 Enterbacteriaceae isolates, Senegal, 2008–2009*

Isolate Species Origin† Resistance genes
MIC (µg/mL)
blaOXA-48 blaCTX-M-15 blaOXA-1 blaTEM aac-6′-Ib qnr tet dfr IPM MEM ERT
17176 Klebsiella pneumoniae 1 + + A,D 1 0.38 1.5
22184 K. pneumoniae 2 + + + + cr S A A1 1 0.38 1.5
20254 K. pneumoniae 3 + + + + cr S A A1 1 0.38 1.5
10243 K .pneumoniae 3 + + + + cr S A A1 1 0.38 1.5
19220 K. pneumoniae 2 + + + + cr B A,D 0.5 0.19 0.75
18212 K. pneumoniae 2 + 3 2 12
18220 K. pneumoniae 3 + + + S D 1 0.38 1.5
06003 K. pneumoniae 4 + 2 0.25 0.75
HPD Enterobacter cloacae 3 + + + + cr B,S B 4 3 8
20247 Enterobacter sakazakii 5 + + + + cr 0.5 1 3
24246 Escherichia coli 4 + + + cr S 2 0.5 2
J53 E. coli 0.12 0.03 0.03
TC E. coli + 0.5 0.19 0.75

*IPM, imipenem; MEM, meropenem; ERT, ertapenem; TC, transconjugants.
†Origin: 1, postsurgical visceral infection; 2, postsurgical orthopedic infection; 3, nosocomial urinary tract infection; 4, community-acquired urinary tract infection; 5, omphalocele infection.
‡Clonally related isolates.

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