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Volume 17, Number 1—January 2011

CME ACTIVITY - Research

Hepatitis E Virus Infection without Reactivation in Solid-Organ Transplant Recipients, France

Florence Legrand-AbravanelComments to Author , Nassim Kamar, Karine Sandres-Saune, Sebastien Lhomme, Jean-Michel Mansuy, Fabrice Muscari, Federico Sallusto, Lionel Rostaing, and Jacques Izopet
Author affiliations: Author affiliations: Institut National de la Santé et de la Recherche Médicale, Toulouse, France (F. Legrand-Abravanel, N. Kamar, K. Sandres-Saune, S. Lhomme, L. Rostaing, J. Izopet); Centre Hospitalier Universitaire Toulouse, Toulouse (F. Legrand-Abravanel, N. Kamar, K. Sandres-Saune, S. Lhomme, J.-M. Mansuy, F. Muscari, F. Sallusto, L. Rostaing, J. Izopet)

Main Article

Table 2

Incidence of HEV per year after transplantation in 601 solid-organ transplant recipients, France, January 2004–December 2008*

Patient group
Incidence, cases/100 person-years (95% confidence interval)
p value
Global
First year
Second year
Third year
Fourth year
All 3.2 (2.06–4.13) 3.5 (1.9–5.1) 1.1 (0.03–2.19) 3.7 (1.09–6.1) 3.0 (0.1–7.52) 0.08
Kidney transplant 2.7 (1.52–3.68) 2.4 (0.8–3.9) 0.9 (0.01–4.4) 3.3 (0.47–6.120) 4.3 (1.28–11.48) 0.18
Liver transplant 4.8 (2.2–7.4) 7.12 (2.63–11.62) 1.6 (0.04–7.60) 5.1 (0.52–14.54) 0 (0–10) 0.24

*HEV, hepatitis E virus.

Main Article

1Based on results from this study, which of the following patients would be anticipated to be at highest risk for acquisition of hepatitis E virus (HEV) infection?

A. A 65-year-old man undergoing kidney transplantation

B. A 45-year-old woman undergoing liver transplantation

C. A 76-year-old man 1 year post liver transplant.

D. A 36-year-old woman 6 months post kidney transplant

2A 49-year-old female patient who is HIV positive undergoes a liver transplant. Six months later she is found to be HEV positive. Which of the following factors would increase her risk to evolve to a chronic infection?

A. Alcohol use

B. Female sex

C. Immunocompromise associated with HIV infection

D. Comorbid hepatitis C virus or hepatitis B virus infection

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