Emerging Infectious Disease ISSN: 1080-6059

Molecular Typing of Protease-Resistant Prion Protein in Transmissible Spongiform Encephalopathies of Small Ruminants, France, 2002–2009

Johann Vulin, Anne-Gaëlle Biacabe, Géraldine Cazeau, Didier Calavas, and Thierry Baron

Author affiliations: Author affiliation: Agence Nationale de Sécurité Sanitaire, Lyon, France

Figure 1

Immunoblots obtained for reference brain samples by discriminatory Western blot method. The first membrane (A, B) was probed with Bar233 antibody. The second membrane (C, D) was probed with monoclonal antibody P4. The 2 immunoblots were loaded with a natural classical bovine spongiform encephalopathy (BSE) isolate (lane 1); an isolate from a sheep experimentally infected with classical BSE 4 (SB1, lanes 2, 6); 2 sheep-passaged scrapie isolates (SSBP/1, lanes 3, 5; CH1641, lane 4); and an isolate

Figure 1. Immunoblots obtained for reference brain samples by discriminatory Western blot method. The first membrane (A, B) was probed with Bar233 antibody. The second membrane (C, D) was probed with monoclonal antibody P4. The 2 immunoblots were loaded with a natural classical bovine spongiform encephalopathy (BSE) isolate (lane 1); an isolate from a sheep experimentally infected with classical BSE 4 (SB1, lanes 2, 6); 2 sheep-passaged scrapie isolates (SSBP/1, lanes 3, 5; CH1641, lane 4); and an isolate from a goat experimentally infected with classical BSE (CH41x76, lane 7).

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