Endurance, Refuge, and Reemergence of Dengue Virus Type 2, Puerto Rico, 1986–2007
Kate L. McElroy1, Gilberto A. Santiago1, Niall J. Lennon, Bruce W. Birren, Matthew R. Henn1, and Jorge L. Muñoz-Jordán1
Author affiliations: Author affiliations: Centers for Disease Control and Prevention, San Juan, Puerto Rico (K.L. McElroy, G.A. Santiago, J.L. Muñoz-Jordán); Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA (N.J. Lennon, B.W. Birren, M.R. Henn)
Figure 4. Epidemiology of dengue virus (DENV) serotype 2 in Puerto Rico, 1997–2006. A) Municipalities with persistent DENV-2 transmission (Caguas, Juncos, Las Piedras, Carolina) versus those with discontinuous transmission (Morovis, Toa Alta, Toa Baja, Cataño, Guaynabo, Cidra, San Lorenzo, Canóvanas, Humacao, Naguabo, Ceiba, Fajardo), 1998–2002. Inset shows satellite view; red dot indicates national capital (San Juan), and yellow box indicates region where DENV-2 took refuge during 2000–2002. B–D) Satellite view depicts virus transmission corridors. White pins point to specific geographic locations where DENV-2 isolates were collected during the specified time period. Yellow lines connect isolates by their phylogenetic affiliations suggesting migration of virus. B) DENV-2 traveled to the San Juan region from the west during 1997–1999; C) DENV-2 transmission retracted to the eastern, refuge region with restricted dispersion patterns during 2000–2002; D) DENV-2 reemerged focused on the San Juan region and later dispersed throughout the island during 2003–2006.
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