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Volume 17, Number 1—January 2011

Dispatch

New Delhi Metallo-β-Lactamase in Klebsiella pneumoniae and Escherichia coli, Canada

Michael R. MulveyComments to Author , Jennifer M. Grant, Katherine Plewes, Diane Roscoe, and David A. Boyd
Author affiliations: Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (M.R. Mulvey, D.A. Boyd); Vancouver General Hospital, Vancouver, British Columbia, Canada (J.M. Grant, K. Plewes, D. Roscoe)

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Table 2

Antimicrobial drug susceptibilities of the isolates from study of New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada, 2010*

Test/antimicrobial agent K. pneumoniae
N10–0469 E. coli DH10B
(pNDM-Kp10469) E. coli N10–0505 E. coli DH10B
(pNDM-Ec10505) E. coli DH10B
Broth microdilution (MIC, μg/mL)
Amoxicillin/clavulanic acid >32 >32 32 >32 4
Piercillin/tazobactam >64 >64 >64 >64 <4
Ampicillin >16 >16 >16 >16 2
Cefazolin >16 >16 >16 >16 <8
Cefotaxime >64 >64 >64 >64 <0.25
Cefotaxime/clavulanic acid >64 >64 >64 >64 <0.12
Ceftazidime >128 >128 >128 >128 <0.25
Ceftazidime/clavulanic acid >128 >128 >128 >128 0.25
Cefepime >16 16 >16 16 <1
Cefoxitin >64 >64 >64 >64 8
Imipenem >16 4 2 2 <0.5
Meropenem >8 2 8 2 <1
Chloramphenicol 16 4 32 4 <2
Tetracycline >32 ≤4 32 ≤4 <4
Amikacin >64 >64 >64 >64 2
Gentamicin >16 >16 >16 >16 <0.25
Ciprofloxacin >2 <0.015 >2 <0.015 <0.015
Trimethoprim/sulfamethoxazole
>4
<0.12
>4
<0.12
<0.12
Etest (MIC, μg/mL)
Aztreonam >256 4 >256 4 0.094
Imipenem >32 4 >32 4 0.19
Meropenem >32 8 32 6 0.032
Ertapenem >32 16 >32 16 0.008
Colistin 0.38 ND 0.38 ND ND
Polymyxin B 0.19 ND 0.25 ND ND
Tigecycline
1.5
ND
0.125
ND
ND
Disk diffusion (zone diameter, mm)
Imipenem 6 14 11 13 33
Meropenem 6 15 10 14 35
Ertapenem 6 13 6 13 35

*NDM, New Delhi metallo-β-lactamase; ND, not done.

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