Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 17, Number 10—October 2011

Dispatch

Yellow Fever Virus Vaccine–associated Deaths in Young Women1

Stephen J. SeligmanComments to Author 
Author affiliation: New York Medical College, Valhalla, New York, USA

Main Article

Table

Characteristics of fatal yellow fever vaccine–associated viscerotropic disease in women of childbearing age who had no known immunologic defects*

Age, y Country Year Vaccine Days after vaccination
Possible predisposing factors Virus detection Neutralizing antibody test results Reference
Onset Death
19 Brazil 2001 17DD† 2 10 None known + RT-PCR liver and spleen (12)
22 United States 2002 17D-204 YF-Vax‡ 2 10 None known YF viral antigen in multiple organs, i.e., liver, lungs, brain, heart, spleen, kidney, lymph nodes (7)
22 United States 2005 17D-204 YF-Vax‡ 2 11 See text for postmortem description of thymus Plasma virus 1.1 × 105 PFU/mL 2,560, day 10 (9)
22 Brazil 2000 17DD† 4 11 Hepatitis A and nephritis as a child + Culture IgM + (2)
23 Peru 2007 17DD† 1 9 Acne rosacea Viral RNA lung 7.6 × 106 and serum 3.9 × 106 PFU equivalents/mL 160 (by PRNT), day 9 (10)
Young adult § Brazil 1975 17DD† 5 9 None known + Culture Table 36-30 in (11), (13)
24 Peru 2007 17DD† <1 14 Egg allergy Viral RNA liver 1.1 × 104 and brain 4.2 × 103 PFU equivalents/mL 10,240 (by PRNT), day 11 (10)
26 Spain 2004 17D-204¶ 4 10 None known + Culture liver, kidney, plasma; real-time PCR liver 6.2 × 109 genome equivalents/g 512 (by microneutralization assay), day 8 (8)
34 Brazil 2009 17DD† 1 11 None known RT-PCR + d 10 #

*+, positive test result; RT-PCR, reverse transcription PCR; YF, yellow fever; Ig, immunoglobulin; PRNT, plaque-reduction neutralization test. Blank cells indicate information is not in the reference cited.
†Bio-Manguinhos, Rio de Janeiro, Brazil.
‡Sanofi Pasteur, Swiftwater, PA, USA.
§The age of this patient is not known, but she was a young woman (P. Vasconcelos, pers. comm.).
¶Stamaril, Sanofi Pasteur, Lyon, France.
#R. Menezes-Martins, pers. comm.

*+, positive test result; RT-PCR, reverse transcription PCR; YF, yellow fever; Ig, immunoglobulin; PRNT, plaque-reduction neutralization test. Blank cells indicate information is not in the reference cited.
†Bio-Manguinhos, Rio de Janeiro, Brazil.
‡Sanofi Pasteur, Swiftwater, PA, USA.
§The age of this patient is not known, but she was a young woman (P. Vasconcelos, pers. comm.).
¶Stamaril, Sanofi Pasteur, Lyon, France.
#R. Menezes-Martins, pers. comm.

Main Article

1Data previously presented at a National Institutes of Health–supported Northeast Biodefense Center conference, New Paltz, New York, USA, November 2, 2010.

TOP