Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 17, Number 10—October 2011

Dispatch

Yellow Fever Virus Vaccine–associated Deaths in Young Women1

Stephen J. SeligmanComments to Author 
Author affiliation: New York Medical College, Valhalla, New York, USA

Main Article

Table

Characteristics of fatal yellow fever vaccine–associated viscerotropic disease in women of childbearing age who had no known immunologic defects*

Age, y Country Year Vaccine Days after vaccination
Possible predisposing factors Virus detection Neutralizing antibody test results Reference
Onset Death
19 Brazil 2001 17DD† 2 10 None known + RT-PCR liver and spleen (12)
22 United States 2002 17D-204 YF-Vax‡ 2 10 None known YF viral antigen in multiple organs, i.e., liver, lungs, brain, heart, spleen, kidney, lymph nodes (7)
22 United States 2005 17D-204 YF-Vax‡ 2 11 See text for postmortem description of thymus Plasma virus 1.1 × 105 PFU/mL 2,560, day 10 (9)
22 Brazil 2000 17DD† 4 11 Hepatitis A and nephritis as a child + Culture IgM + (2)
23 Peru 2007 17DD† 1 9 Acne rosacea Viral RNA lung 7.6 × 106 and serum 3.9 × 106 PFU equivalents/mL 160 (by PRNT), day 9 (10)
Young adult § Brazil 1975 17DD† 5 9 None known + Culture Table 36-30 in (11), (13)
24 Peru 2007 17DD† <1 14 Egg allergy Viral RNA liver 1.1 × 104 and brain 4.2 × 103 PFU equivalents/mL 10,240 (by PRNT), day 11 (10)
26 Spain 2004 17D-204¶ 4 10 None known + Culture liver, kidney, plasma; real-time PCR liver 6.2 × 109 genome equivalents/g 512 (by microneutralization assay), day 8 (8)
34 Brazil 2009 17DD† 1 11 None known RT-PCR + d 10 #

*+, positive test result; RT-PCR, reverse transcription PCR; YF, yellow fever; Ig, immunoglobulin; PRNT, plaque-reduction neutralization test. Blank cells indicate information is not in the reference cited.
†Bio-Manguinhos, Rio de Janeiro, Brazil.
‡Sanofi Pasteur, Swiftwater, PA, USA.
§The age of this patient is not known, but she was a young woman (P. Vasconcelos, pers. comm.).
¶Stamaril, Sanofi Pasteur, Lyon, France.
#R. Menezes-Martins, pers. comm.

*+, positive test result; RT-PCR, reverse transcription PCR; YF, yellow fever; Ig, immunoglobulin; PRNT, plaque-reduction neutralization test. Blank cells indicate information is not in the reference cited.
†Bio-Manguinhos, Rio de Janeiro, Brazil.
‡Sanofi Pasteur, Swiftwater, PA, USA.
§The age of this patient is not known, but she was a young woman (P. Vasconcelos, pers. comm.).
¶Stamaril, Sanofi Pasteur, Lyon, France.
#R. Menezes-Martins, pers. comm.

Main Article

1Data previously presented at a National Institutes of Health–supported Northeast Biodefense Center conference, New Paltz, New York, USA, November 2, 2010.

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO