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Volume 17, Number 10—October 2011

CME ACTIVITY - Research

Invasive Non-Aspergillus Mold Infections in Transplant Recipients, United States, 2001–2006

Benjamin J. ParkComments to Author , Peter G. Pappas, Kathleen A. Wannemuehler, Barbara D. Alexander, Elias J. Anaissie, David R. Andes, John W. Baddley, Janice M. Brown, Lisa M. Brumble, Alison G. Freifeld, Susan Hadley, Loreen Herwaldt, James I. Ito, Carol A. Kauffman, G. Marshall Lyon, Kieren A. Marr, Vicki A. Morrison, Genovefa Papanicolaou, Thomas F. Patterson, Trish M. Perl, Mindy G. Schuster, Randall Walker, John R. Wingard, Thomas J. Walsh, and Dimitrios P. Kontoyiannis

Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (B.J. Park, K.A. Wannemuehler); University of Alabama at Birmingham Medical Center, Birmingham, Alabama, USA (P.G. Pappas, J.W. Baddley); Duke University Medical Center, Durham, North Carolina, USA (B.D. Alexander); University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA (E.J. Anaissie); University of Wisconsin–Madison, Madison, Wisconsin, USA (D.R. Andes); Stanford University School of Medicine, Stanford, California, USA (J.M. Brown); Mayo Clinic, Jacksonville, Florida, USA (L.M. Brumble); University of Nebraska Medical Center, Omaha, Nebraska, USA (A.G. Freifeld); Tufts Medical Center, Boston, Massachusetts, USA (S. Hadley); University of Iowa Hospital, Iowa City, Iowa, USA (L. Herwaldt); City of Hope National Medical Center, Duarte, California, USA (J.I. Ito); University of Michigan, Ann Arbor, Michigan, USA (C.A. Kauffman); Veterans Affairs Ann Arbor Healthcare System–Medicine, Ann Arbor (C.A. Kauffman); Emory University School of Medicine, Atlanta (G.M. Lyon); Johns Hopkins Medical Institutions, Baltimore, Maryland, USA (K.A. Marr, T.M. Perl); Fred Hutchinson Cancer Research Center, Seattle, Washington, USA (K.A. Marr); University of Minnesota, Minneapolis, Minnesota, USA (V.A. Morrison); Veterans Affairs Medical Center, Minneapolis (V.A. Morrison); Memorial Sloan Kettering Cancer Center, New York, New York, USA (G. Papanicolaou); University of Texas Health Sciences Center, San Antonio, Texas, USA (T.F. Patterson); South Texas Veterans Healthcare System, San Antonio (T.F. Patterson); Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA (M.G. Schuster); Mayo Clinic, Rochester, Minnesota, USA (R. Walker); University of Florida, Gainesville, Florida, USA (J.R. Wingard); National Institutes of Health, Bethesda, Maryland, USA (T.J. Walsh); MD Anderson Cancer Center, Houston, Texas, USA (D.P. Kontoyiannis)

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Table 1

Distribution of Mucorales, Fusarium, and Scedosporium organisms causing infection in HCT and SOT recipients, as detected in TRANSNET, United States, 2001–2006*

Organism No. (%) patients
HCT SOT Total
Mucorales 77 (62.1) 28 (62.2) 105 (62.1)
Rhizopus spp. 39 (50.6) 16 (57.1) 55 (52.4)
Mucor spp. 12 (15.6) 7 (25.0) 19 (18.1)
Rhizomucor spp. 7 (9.1) 0 7 (6.7)
Cunninghamella spp. 5 (6.5) 4 (14.3) 9 (8.6)
Lichtheimia spp.† 3 (3.9) 0 3 (2.9)
Apophysomyces spp. 1 (1.3) 0 1 (1.0)
Syncephalastrum spp. 1 (1.3) 0 1 (1.0)
Unspecified
9 (11.7)
1 (3.6)
10 (9.5)
Genus Fusarium 31 (25.0) 6 (13.3) 37 (21.9)
F. solani 9 (29.0) 1 (16.7) 10 (27.0)
F. oxysporum 0 2 (33.3) 2 (5.4)
F. proliferatum 2 (6.5) 0 2 (5.4)
F. verticilloides 1 (3.2) 0 1 (2.7)
Unspecified
19 (61.3)
3 (50.0)
22 (59.5)
Genus Scedosporium 16 (12.9) 11 (24.4) 27 (16.0)
S. apiospermum 13 (81.3) 6 (54.5) 19 (70.4)
S. prolificans 3 (18.8) 5 (45.5) 8 (29.6)
Total 124 (73.4) 45 (26.6) 169 (100)

*HCT, hematopoietic cell transplant; SOT, solid organ transplant; TRANSNET, Transplant-Associated Infection Surveillance Network.
†This genus was formerly Absidia.

*HCT, hematopoietic cell transplant; SOT, solid organ transplant; TRANSNET, Transplant-Associated Infection Surveillance Network.
†This genus was formerly Absidia.

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