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Volume 17, Number 10—October 2011
Research

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infection in England and Scotland, 2009–2010

Laurence CalatayudComments to Author , Angie Lackenby, Arlene Reynolds, Jim McMenamin, Nick F. Phin, Maria Zambon, and Richard G. Pebody
Author affiliations: Health Protection Agency, London, UK (L. Calatayud, A. Lackenby, N.F. Phin, M.C. Zambon, R. Pebody); Health Protection Scotland, Glasgow, Scotland, UK (A. Reynolds, J. McMenamin)

Main Article

Table 1

Distribution and reported associations of age, sex, and underlying medical conditions of study case-patients and controls hospitalized for pandemic (H1N1) 2009, England and Scotland, April 27, 2009–April, 30, 2010*

Patient characteristic No. (%) case-patients, n = 34
No. (%) controls, n = 346
OR (95% CI)
n With characteristic n With characteristic Crude Adjusted†
Sex
M 34 23 (67.6) 346 155 (44.8) 0.4 (0.2–0.9) 0.4 (0.2–1.2)
F
34
11 (32.4)

346
191 (55.2)



Age group, y
0–4 34 4 (11.8) 346 64 (18.5) 1 1
5–14 34 4 (11.8) 346 83 (23.9) 0.8 (0.2–3.2) 0.5 (0.1–3.4)
15–24 34 1 (2.9) 346 59 (17.1) 0.3 (0.1–2.5) 1
25–44 34 4 (11.8) 346 74 (21.4) 0.9 (0.2–3.6) 0.5 (0.1–3.6)
45–64 34 16 (47.1) 346 56 (16.2) 4.6 (1.4–14.5) 2.4 (0.5–11.1)
>65
34
5 (14.7)

346
10 (2.9)

8.0 (1.8–34.9)
4.1 (0.5–31.3)
Any underlying condition 30 28 (93.3) 278 164 (60.0) 9.7(2.4–85.5)
Respiratory 28 7 (25.0) 284 94 (33.1) 0.8 (0.3–2.1)
Cardiac 28 3 (10.7) 273 12 (4.4) 3.0 (0.5–12.1)
Renal 28 1 (3.6) 275 11 (4.0) 1.0 (0.0–7.4)
Liver 28 3 (10.7) 272 3 (1.1) 12.2 (1.5–95.0)
Neurologic 28 3 (10.7) 269 15 (5.6) 2.3 (0.4–9.1)
Immunosuppression 28 21 (75.0) 275 19 (6.9) 35.4 (12.7–102.1) 18.1 (6.6–49.9)
Diabetes 28 4 (14.3) 276 6 (2.2) 9.0 (1.7–41.0)
Pregnancy 28 0 301 19 (6.3)
Other chronic disease 28 6 (21.4) 258 32 (12.4) 2.5 (0.7–7.2)

*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval.
†OR adjusted for age, sex, and underlying conditions (e.g., immunosuppression, chronic respiratory diseases).

*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval.
†OR adjusted for age, sex, and underlying conditions (e.g., immunosuppression, chronic respiratory diseases).

Main Article

Page created: September 28, 2011
Page updated: September 28, 2011
Page reviewed: September 28, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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