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Volume 17, Number 10—October 2011

Research

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus Infection in England and Scotland, 2009–2010

Laurence CalatayudComments to Author , Angie Lackenby, Arlene Reynolds, Jim McMenamin, Nick F. Phin, Maria Zambon, and Richard G. Pebody
Author affiliations: Health Protection Agency, London, UK (L. Calatayud, A. Lackenby, N.F. Phin, M.C. Zambon, R. Pebody); Health Protection Scotland, Glasgow, Scotland, UK (A. Reynolds, J. McMenamin)

Main Article

Table 1

Distribution and reported associations of age, sex, and underlying medical conditions of study case-patients and controls hospitalized for pandemic (H1N1) 2009, England and Scotland, April 27, 2009–April, 30, 2010*

Patient characteristic No. (%) case-patients, n = 34
No. (%) controls, n = 346
OR (95% CI)
n With characteristic n With characteristic Crude Adjusted†
Sex
M 34 23 (67.6) 346 155 (44.8) 0.4 (0.2–0.9) 0.4 (0.2–1.2)
F
34
11 (32.4)

346
191 (55.2)



Age group, y
0–4 34 4 (11.8) 346 64 (18.5) 1 1
5–14 34 4 (11.8) 346 83 (23.9) 0.8 (0.2–3.2) 0.5 (0.1–3.4)
15–24 34 1 (2.9) 346 59 (17.1) 0.3 (0.1–2.5) 1
25–44 34 4 (11.8) 346 74 (21.4) 0.9 (0.2–3.6) 0.5 (0.1–3.6)
45–64 34 16 (47.1) 346 56 (16.2) 4.6 (1.4–14.5) 2.4 (0.5–11.1)
>65
34
5 (14.7)

346
10 (2.9)

8.0 (1.8–34.9)
4.1 (0.5–31.3)
Any underlying condition 30 28 (93.3) 278 164 (60.0) 9.7(2.4–85.5)
Respiratory 28 7 (25.0) 284 94 (33.1) 0.8 (0.3–2.1)
Cardiac 28 3 (10.7) 273 12 (4.4) 3.0 (0.5–12.1)
Renal 28 1 (3.6) 275 11 (4.0) 1.0 (0.0–7.4)
Liver 28 3 (10.7) 272 3 (1.1) 12.2 (1.5–95.0)
Neurologic 28 3 (10.7) 269 15 (5.6) 2.3 (0.4–9.1)
Immunosuppression 28 21 (75.0) 275 19 (6.9) 35.4 (12.7–102.1) 18.1 (6.6–49.9)
Diabetes 28 4 (14.3) 276 6 (2.2) 9.0 (1.7–41.0)
Pregnancy 28 0 301 19 (6.3)
Other chronic disease 28 6 (21.4) 258 32 (12.4) 2.5 (0.7–7.2)

*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval.
†OR adjusted for age, sex, and underlying conditions (e.g., immunosuppression, chronic respiratory diseases).

*Case-patients were those with osteltamivir-resistant pandemic (H1N1) 2009 strains; controls were those with osteltamir-sensitive pandemic (H1N1) 2009 strains. n indicates no. patients with information available for that category. OR, odds ratio; CI, confidence interval.
†OR adjusted for age, sex, and underlying conditions (e.g., immunosuppression, chronic respiratory diseases).

Main Article

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