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Volume 17, Number 11—November 2011
THEME ISSUE
CHOLERA IN HAITI

Research

Comparative Genomics of Vibrio cholerae from Haiti, Asia, and Africa

Aleisha R. Reimer, Gary Van Domselaar, Steven Stroika, Matthew Walker, Heather Kent, Cheryl Tarr, Deborah Talkington, Lori Rowe, Melissa Olsen-Rasmussen, Michael Frace, Scott A. Sammons, Georges Anicet Dahourou, Jacques Boncy, Anthony M. Smith, Philip Mabon, Aaron Petkau, Morag Graham, Matthew W. Gilmour, Peter Gerner-SmidtComments to Author , and the V. cholerae Outbreak Genomics Task Force
Author affiliations: Author affiliations: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A.R. Reimer, G. Van Domselaar, M. Walker, H. Kent, P. Mabon, A. Petkau, M. Graham, M.W. Gilmour); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Stroika, C. Tarr, D. Talkington, L. Rowe, M. Olsen-Rasmussen, M. Frace, S. Sammons, P. Gerner-Smidt); Centers for Disease Control and Prevention, Port-au-Prince, Haiti (G.A. Dahourou); Ministry of Public Health and Population, Port-au-Prince (J. Boncy); National Institute for Communicable Diseases, Johannesburg, South Africa (A.M. Smith)

Main Article

Table 1

Characteristics of Vibrio cholerae isolates from Haiti, Asia, Africa, and the United States*

Isolate Serotype ctxB allele† PFGE patterns
Date of collection Origin of infection Comment or GenBank accession no. (reference)
SfiI NotI
2010EL-1961 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Oct 17 Haiti Earliest Haiti outbreak case
2010EL-1786 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Artibonite, Haiti None
2010EL-1792 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Artibonite, Haiti None
2010EL-1798 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Haiti None
2010EL-2010N Ogawa B-7 KZGS12.0160 KZGN11.0134 2010 Haiti Nonhemolytic
2010EL-2010H Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Haiti Hemolytic
2011EL-1089 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Nov 27 South Department, Haiti None
2011EL-1133 Ogawa B-7 KZGS12.0088 KZGN11.0092 2011 Jan 26 Northwest Department, Haiti Travel associated
2011V-1021 Ogawa B-7 KZGS12.0088 KZGN11.0092 2011 Dominican Republic Travel associated
2009V-1085 Ogawa B-7 KZGS12.0088 KZGN11.0092 2009 Sri Lanka/India Travel associated
2009V-1096 Inaba B-7 KZGS12.0088 KZGN11.0092 2009 India Travel associated
2010EL-1749 Ogawa B-7 KZGS12.0088 KZGN11.0092 2010 Cameroon Outbreak
2009V-1131 Ogawa B-7 KZGS12.0088 KZGN11.0092 2009 India Travel associated
3554–08 Ogawa B-7 KZGS12.0088 KZGN11.0092 2008 Nepal Travel associated
2011EL-1137 Ogawa B-1 KZGS12.0089 KZGN11.0092 2009 South Africa Outbreak
2009V-1046 Ogawa B-1 KZGS12.0088 KZGN11.0092 2009 Pakistan Travel associated
2009V-1116 Ogawa B-1 KZGS12.0088 KZGN11.0092 2009 Pakistan Travel associated
2010V-1014 Ogawa B-1 KZGS12.0088 KZGN11.0092 2010 Pakistan Travel associated
3582–05 Inaba B-1 KZGS12.0088 KZGN11.0092 2005 Pakistan Travel associated
3500–05 Inaba B-1 KZGS12.0088 KZGN11.0092 2005 India Travel associated
3546–06 Inaba B-1 KZGS12.0088 KZGN11.0092 2006 India Travel associated
3569–08 Inaba B-1 KZGS12.0055 KZGN11.0029 2008 US Gulf Coast Environmental isolate
C6706 Inaba B-3 KZGS12.0114 KZGN11.0033 1991 Peru Latin America outbreak
CIRS101‡ Inaba B-1 Unknown Unknown 2002 Dhaka, Bangladesh NZ_ACVW00000000 (4)
MJ-1236‡ Inaba B-1 Unknown Unknown 1994 Matlab, Bangladesh NC_012667, NC_012668 (4)
O395‡ Ogawa B-1 Unknown Unknown 1965 India NC_009456, NC_009457 (1)
N16961‡ Inaba B-3 Unknown Unknown 1970s Bangladesh NC_002505, NC_002506 (13)
M66–2‡ Unknown § Unknown Unknown 1937 Makassar, Indonesia NC_012578, NC_012580 (1)

*ctxB, cholera toxin subunit B; PFGE, pulsed-field gel electrophoresis.
†B-7, classical allele, Orissa variant; B-1, classical allele; B-3, El Tor allele (2)
‡These isolates have been sequenced by other investigators, and sequences have been deposited in GenBank. PFGE was not performed on these isolates.
§This isolate does not contain ctxB.

Main Article

1Members of the V. cholerae Outbreak Genomics Task Force are Arunmozhi Balajee, Shanna Bolcen, Cheryl A. Bopp, John Besser, Ifeoma Ezeoke, Patricia Fields, Molly Freeman, Lori Gladney, Dhwani Govil, Michael S. Humphrys, Maria Sjölund-Karlsson, Karen H. Keddy, Elizabeth Neuhaus, Michele M. Parsons, Efrain Ribot, Maryann Turnsek, Shaun Tyler, Jean M. Whichard, Anne Whitney, and the authors.

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