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Volume 17, Number 12—December 2011

Letter

Humans as Source of Mycobacterium tuberculosis Infection in Cattle, Spain

Beatriz Romero, Sabrina Rodríguez, Javier Bezos, Rosa Díaz, M. Francisca Copano, Isabel Merediz, Olga Mínguez, Sergio Marqués, Juan J. Palacios, Darío García de Viedma, José Luis Sáez, Ana Mateos, Alicia Aranaz, Lucas Domínguez, and Lucía de JuanComments to Author 
Author affiliations: Universidad Complutense, Madrid, Spain (B. Romero, S. Rodríguez, J. Bezos, A. Mateos, A. Aranaz, L. Domínguez, L. de Juan); Consejería de Medio Ambiente, Vivienda y Ordenación del Territorio, Madrid (R. Díaz); Laboratorio de Sanidad Animal de Jove, Gijón, Spain (M.F. Copano, I. Merediz); Consejería de Agricultura y Ganadería, Valladolid, Spain (O. Mínguez, S. Marqués); Hospital Universitario Central de Asturias, Oviedo, Spain (J.J. Palacios); Hospital General Universitario Gregorio Marañón, Madrid, and Centro de Investigación Biomédica en Red Enfermedades Respiratorias Enfermedades Respiratorias, Madrid (D. García de Viedma); Ministerio de Medio Ambiente, y Medio Rural y Marino, Madrid (J.L. Sáez)

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Table

Relevant information about Mycobacterium tuberculosis infection in 3 cattle farms in Spain*

Variable Farm 1 Farm 2 Farm 3
Cattle herd
No. animals 6 54 >200
Production Beef Beef Dairy
Previous status TB free TB-free Non–TB free
No. reactors
1
31
12
M. tuberculosis infection in cattle
Year of isolation 2007 2008 2009
Age, mo 9 4 3
IDTB/interferon-γ Pos/not determined Neg/neg Pos/not determined
TB-compatible lesion No No No
Spoligotyping profile SIT2537 SIT1564 SIT58
MIRU-VNTR profile† 253533233433236252211423 3′52334232455457251213423 254343243232325262213423
Co-infection with
other mycobacteria
Yes
(M. avium subsp. hominissuis)‡
Yes
(M. bovis)
No
M. tuberculosis infection in human
Active tuberculosis Yes Yes Yes
Spoligotyping profile SIT2537 Not available SIT58
MIRU-VNTR profile† 253533233433236252211423 3′52334232455457251213423 254343243232325262213423
Origin Spain Eastern Europe Spain

*TB, tuberculosis; IDTB, intradermal tuberculin tested according to the European Council Directive 64/432/EEC; pos, positive; neg, negative; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat.
†MIRU-VNTR profile on the basis of the 24 MIRU-VNTR loci (7).
‡Co-infection in the same animal.

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