Isolation of Prion with BSE Properties from Farmed Goat
Figure 5. Lesion profiles from VM mice after second passage of the suspected case, serial passage of an ovine bovine spongiform encephalopathy (BSE) source, and a 301V control. Profiles were made on the basis of the lesion score, which is the quantification of transmissible spongiform encephalopathy–specific vacuolation in 9 neuroanatomical gray matter areas: G1, dorsal medulla nuclei; G2, cerebellar cortex of the folia including the granular layer, adjacent to the fourth ventricle; G3, cortex of the superior colliculus; G4, hypothalamus; G5, thalamus; G6, hippocampus; G7, septal nuclei of the paraterminal body; G8, cerebral cortex (at the level of G4 and G5); G9, cerebral cortex (at the level of G7). At least 9 clinically and histopathologically positive mice contributed to each profile. Error bars indicate SEM.