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Volume 17, Number 12—December 2011

Research

Candidate Cell Substrates, Vaccine Production, and Transmissible Spongiform Encephalopathies

Pedro PiccardoComments to Author , Larisa Cervenakova, Irina Vasilyeva, Oksana Yakovleva, Igor Bacik, Juraj Cervenak, Carroll McKenzie, Lubica Kurillova, Luisa Gregori, Kitty Pomeroy, and David M. Asher
Author affiliations: University of Edinburgh, Easter Bush, UK, (P. Piccardo); Food and Drug Administration, Kensington, Maryland, USA (P. Piccardo, I. Bacik, J. Cervenak, L. Kurillova, L. Gregori, K. Pomeroy, D.M. Asher); Holland Laboratory American Red Cross, Rockville, Maryland, USA (L. Cervenakova, I. Vasilyeva, O. Yakovleva, C. McKenzie)

Main Article

Table 1

Cell cultures exposed to transmissible spongiform encephalopathy agents and propagated for 30 passages*

Variable sCJD vCJD BSE 22L-scrapie
Actual or candidate cell lines for vaccine production
CHO-K1 Y Y Y
Vero C1008 Y Y Y
WI-38 Y Y Y
MDCK Y Y Y
HEK-293 Y Y Y
Other cells resistant to TSE infection
MBDK Y
EBTR Y
BT Y
BCE C/D-1b Y
BL3.1 Y
R9ab Y Y Y
Cells infectable with 22L scrapie
Mo3F4-3T3 Y
L929 Y

*sCJD, sporadic Creutzfeldt-Jakob disease; vCJD, variant Creutzfeldt-Jakob disease; BSE, bovine spongiform encephalopathy; CHO-KI, Chinese hamster ovary; Vero C1008, African green monkey kidney; WI-38, human lung diploid fibroblasts; MDCK, dog kidney; HEK-293, human embryonic kidney; MBDK, bovine kidney; EBTR, bovine trachea; BT, bovine turbinate; BCE C/D-1b, bovine cornea; BL3.1, bovine B lymphocytes; R9ab, rabbit fibroblasts; Mo3F4-3T3, mouse embryo fibroblasts; L929, mouse embryo fibroblasts; Y, experiment was completed.

Main Article

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