TY - JOUR AU - Ahuka-Mundeke, Steve AU - Ayouba, Ahidjo AU - Mbala-Kingebeni, Placide AU - Liegeois, Florian AU - Esteban, Amandine AU - Lunguya-Metila, Octavie AU - Demba, Didace AU - Bilulu, Guy AU - Mbenzo-Abokome, Valentin AU - Inogwabini, Bila-Isia AU - Muyembe-Tamfum, Jean-Jacques AU - Delaporte, Eric AU - Peeters, Martine T1 - Novel Multiplexed HIV/Simian Immunodeficiency Virus Antibody Detection Assay T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 12 SP - 2277 SN - 1080-6059 AB - Like most emerging infectious disease viruses, HIV is also of zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster. KW - HIV KW - simian immunodeficiency virus KW - SIV KW - viruses KW - Democratic Republic of the Congo KW - Africa KW - nonhuman primates KW - bushmeat KW - multiplexed antibody detection assay KW - Democratic Republic of Congo DO - 10.3201/eid1712.110783 UR - https://wwwnc.cdc.gov/eid/article/17/12/11-0783_article ER - End of Reference