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Volume 17, Number 12—December 2011

Dispatch

Novel Sylvatic Rabies Virus Variant in Endangered Golden Palm Civet, Sri Lanka

Takashi Matsumoto, Kamruddin AhmedComments to Author , Omala Wimalaratne, Susilakanthi Nanayakkara, Devika Perera, Dushantha Karunanayake, and Akira Nishizono
Author affiliations: Oita University, Yufu, Japan (T. Matsumoto, K. Ahmed, A. Nishizono); Medical Research Institute, Colombo, Sri Lanka (O. Wimalaratne, S. Nanayakkara, D. Perera, D. Karunanayake)

Main Article

Table 2

Substitutions in genome sequence of rabies virus strain H-1413-09 from Sri Lanka, compared with genome sequence of strain H-08-1320*

Protein, amino acid substitution Site/domain/region of protein†
N
Leu80 → Phe80
Glu110 → Asp110
Ile246 → Val246
Ala372 → Val372
Antigenic site I
P
Gln167 → Arg167
N protein binding site in variable domain II
M
Ile16 → Ala16
Pro19 → Ser19
Ile55 → Val55
Lys77 → Arg77

G
Val193 → Ile193
Arg264 → His264
Ile449 → Thr449 Transmembrane region
Thr459 → Ile459 Transmembrane region
Ala467 → Thr467 Cytoplasmic domain
Glu475 → Gly457 Cytoplasmic domain
Asn499 → Ser499
Cytoplasmic domain
L
Ser26 → Pro26
Ile49 → Leu49
Cys137 → Tyr137
Leu222 → Ile222
Ser312 → Gln312 Conserved domain I
Glu313 → Lys313 Conserved domain I
Ser314 → Ala314 Conserved domain I
Arg315 → Glu315 Conserved domain I
Val317 → Phe317 Conserved domain I
Lys1056 → Arg1056 Conserved domain IV
Thr1137 → Val1137 Conserved domain V
Ala1520 → Glu1520
Ile1555 → Val1555
Leu1570 → Met1570
Met1577 → Leu1577
Lys1625 → Arg1625
Asn1763 → Asp1763
Arg1876 → His1876
Asn2023 → Asp1763
Gly2098 → Arg2098
Leu2113 → Phe2113

*H-08-1320 is a human strain typical of canine rabies virus circulating in Sri Lanka; H-1413-09 is a novel sylvatic rabies virus variant from a golden palm civet in Sri Lanka.
†Blank spaces indicate no site/domain/region has been identified in that portion of the protein.

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