TY - JOUR AU - Marsh, Glenn A. AU - Haining, Jessica AU - Hancock, Timothy AU - Robinson, Rachel AU - Foord, Adam AU - Barr, Jennifer A. AU - Riddell, Shane AU - Heine, Hans AU - White, John AU - Crameri, Gary AU - Field, Hume E. AU - Wang, Lin-Fa AU - Middleton, Deborah T1 - Experimental Infection of Horses with Hendra Virus/Australia/Horse/2008/Redlands T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 12 SP - 2232 SN - 1080-6059 AB - Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus harbored by Australian flying foxes with sporadic spillovers directly to horses. Although the mode and critical control points of HeV spillover to horses from flying foxes, and the risk for transmission from infected horses to other horses and humans, are poorly understood, we successfully established systemic HeV disease in 3 horses exposed to Hendra virus/Australia/Horse/2008/Redlands by the oronasal route, a plausible route for natural infection. In 2 of the 3 animals, HeV RNA was detected continually in nasal swabs from as early as 2 days postexposure, indicating that systemic spread of the virus may be preceded by local viral replication in the nasal cavity or nasopharynx. Our data suggest that a critical factor for reducing HeV exposure risk to humans includes early consideration of HeV in the differential diagnosis and institution of appropriate infection control procedures. KW - KW - Hendra virus KW - infection KW - horses KW - viruses KW - zoonoses KW - Australia KW - HeV KW - experimental DO - 10.3201/eid1712.111162 UR - https://wwwnc.cdc.gov/eid/article/17/12/11-1162_article ER - End of Reference