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Volume 17, Number 2—February 2011

Dispatch

Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Mexico

José Ernesto Ramirez-Gonzalez, Elizabeth Gonzalez-Duran, Patricia Alcantara-Perez, Claudia Wong-Arambula, Hiram Olivera-Diaz, Iliana Cortez-Ortiz, Gisela Barrera-Badillo, Ha Nguyen, Larisa Gubareva, Irma Lopez-Martinez, Jose Alberto Díaz-Quiñonez, Miguel Angel Lezana-Fernández, Hugo Lopez Gatell-Ramírez, Jose Angel Cordova Villalobos, Mauricio Hernández-Avila, and Celia Alpuche-ArandaComments to Author 
Author affiliations: Author affiliations: Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico City, Mexico (J.E. Ramirez-Gonzalez, E. Gonzalez-Duran, P. Alcantara-Perez, C. Wong-Arambula, H. Olivera-Diaz, I. Cortez-Ortiz, G. Barrera-Badillo, I. Lopez-Martinez, J.A. Díaz-Quiñonez, M.A. Lezana-Fernández, H.L. Gatell-Ramírez, J.A.; Cordova Villalobos, M. Hernández-Avila, C. Alpuche-Aranda); Secretaría de Salud, Mexico City (J.E. Ramirez-Gonzalez, E. Gonzalez-Duran, P. Alcantara-Perez, C. Wong-Arambula, H. Olivera-Diaz, I. Cortez-Ortiz, G. Barrera-Badillo, I. Lopez-Martinez, J.A. Díaz-Quiñonez, M.A. Lezana-Fernández, H.L. Gatell-Ramírez, J.A. Cordova Villalobos, M. Hernández-Avila, C. Alpuche-Aranda); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (H. Nguyen, L. Gubareva)

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Figure 2

DNA sequence electropherograms for neuraminidase (NA) gene sequences. A) Analysis of molecular markers (V116, I117, E119, Q136, K150, D151, D198, I223, H275, and N295) for oseltamivir and/or zanamivir resistance among the pandemic (H1N1) 2009 virus isolates. The oseltamivir resistance–conferring mutation CAC (histidine) to TAC (tyrosine) at position 275 was detected in the InDRE797 sample. B) Detection of the H275Y mutation in the NA of the viruses by single-nucleotide polymorphism analysis at N

Figure 2. DNA sequence electropherograms for neuraminidase (NA) gene sequences. A) Analysis of molecular markers (V116, I117, E119, Q136, K150, D151, D198, I223, H275, and N295) for oseltamivir and/or zanamivir resistance among the pandemic (H1N1) 2009 virus isolates. The oseltamivir resistance–conferring mutation CAC (histidine) to TAC (tyrosine) at position 275 was detected in the InDRE797 sample. B) Detection of the H275Y mutation in the NA of the viruses by single-nucleotide polymorphism analysis at NA275 position (yellow area).

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