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Volume 17, Number 2—February 2011

Research

Severe Cases of Pandemic (H1N1) 2009 in Children, Germany

Mathias AltmannComments to Author , Lena Fiebig, Jana Soyka, Rüdiger von Kries, Manuel Dehnert, and Walter Haas
Author affiliations: Author affiliations: Robert Koch Institute, Berlin, Germany (M. Altmann, L. Fiebig, J. Soyka, M. Dehnert, W. Haas); Ludwig-Maximilians-Universität, Munich, Germany (R. von Kries)

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Table 2

Clinical diagnosis for children with severe pandemic (H1N1) 2009, Germany, 2009–2010*

Clinical diagnosis Total† Nonsurvivors not in PICU† Admitted to PICU
Survivors† Nonsurvivors† Subtotal† p value OR (95% CI)
Pneumonia 70/93 (75) 4/4 (100) 59/78 (76) 7/11 (64) 66/89 (74) 0.465 0.6 (0.1–2.9)
ARDS 22/93 (24) 0/4 (0) 15/78 (19) 7/11 (64) 22/89 (25) 0.004 7.4 (1.6–37.8)
Secondary pneumonia 15/93 (16) 0/4 (0) 13/78 (17) 2/11 (18) 15/89 (17) 1 1.1 (0.1–6.3)
Bronchitis/bronchiolitis 12/93 (13) 1/4 (25) 10/78 (13) 1/11 (9) 11/89 (12) 1 0.7 (0.0–5.8)
Encephalopathy 6/93 (6) 0/4 (0) 5/78 (6) 1/11 (9) 6/89 (7) 0.558 1.5 (0.0–15.1)
Sepsis 6/93 (6) 1/4 (25) 5/78 (6) 0/11 (0) 5/89 (6) 1 0.0 (0.0–5.6)
Status asthmaticus 2/93 (2) 0/4 (0) 2/78 (3) 0/11 (0) 2/89 (2) 1 0.0 (0.0–14.5)
Febrile seizure 2/93 (2) 0/4 (0) 2/78 (3) 0/11 (0) 2/89 (2) 1 0.0 (0.0–14.5)
Myocarditis 2/93 (2) 0/4 (0) 1/78 (1) 1/11 (9) 2/89 (2) 0.233 7.7 (0.1–611.9)
Other diagnosis‡ 26/93 (28) 0/4 (0) 21/78 (27) 5/11 (45) 26/89 (29) 0.287 2.3 (0.5–9.9)

*Values are no. positive/no. with available information (%) except as indicated. PICU, pediatric intensive care unit; OR, odds ratio; CI, confidence interval; ARDS, acute respiratory distress syndrome. ORs were calculated only among the cases admitted to the PICU.
†Children may have had >1 diagnosis.
‡Acute exacerbation of a chronic disease or new diagnosis.

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