Volume 17, Number 2—February 2011
Research
Severe Cases of Pandemic (H1N1) 2009 in Children, Germany
Mathias Altmann
, Lena Fiebig, Jana Soyka, Rüdiger von Kries, Manuel Dehnert, and Walter Haas
, Lena Fiebig, Jana Soyka, Rüdiger von Kries, Manuel Dehnert, and Walter HaasTable 2
Clinical diagnosis for children with severe pandemic (H1N1) 2009, Germany, 2009–2010*
| Clinical diagnosis | Total† | Nonsurvivors not in PICU† | Admitted to PICU |
||||
|---|---|---|---|---|---|---|---|
| Survivors† | Nonsurvivors† | Subtotal† | p value | OR (95% CI) | |||
| Pneumonia | 70/93 (75) | 4/4 (100) | 59/78 (76) | 7/11 (64) | 66/89 (74) | 0.465 | 0.6 (0.1–2.9) |
| ARDS | 22/93 (24) | 0/4 (0) | 15/78 (19) | 7/11 (64) | 22/89 (25) | 0.004 | 7.4 (1.6–37.8) |
| Secondary pneumonia | 15/93 (16) | 0/4 (0) | 13/78 (17) | 2/11 (18) | 15/89 (17) | 1 | 1.1 (0.1–6.3) |
| Bronchitis/bronchiolitis | 12/93 (13) | 1/4 (25) | 10/78 (13) | 1/11 (9) | 11/89 (12) | 1 | 0.7 (0.0–5.8) |
| Encephalopathy | 6/93 (6) | 0/4 (0) | 5/78 (6) | 1/11 (9) | 6/89 (7) | 0.558 | 1.5 (0.0–15.1) |
| Sepsis | 6/93 (6) | 1/4 (25) | 5/78 (6) | 0/11 (0) | 5/89 (6) | 1 | 0.0 (0.0–5.6) |
| Status asthmaticus | 2/93 (2) | 0/4 (0) | 2/78 (3) | 0/11 (0) | 2/89 (2) | 1 | 0.0 (0.0–14.5) |
| Febrile seizure | 2/93 (2) | 0/4 (0) | 2/78 (3) | 0/11 (0) | 2/89 (2) | 1 | 0.0 (0.0–14.5) |
| Myocarditis | 2/93 (2) | 0/4 (0) | 1/78 (1) | 1/11 (9) | 2/89 (2) | 0.233 | 7.7 (0.1–611.9) |
| Other diagnosis‡ | 26/93 (28) | 0/4 (0) | 21/78 (27) | 5/11 (45) | 26/89 (29) | 0.287 | 2.3 (0.5–9.9) |
*Values are no. positive/no. with available information (%) except as indicated. PICU, pediatric intensive care unit; OR, odds ratio; CI, confidence interval; ARDS, acute respiratory distress syndrome. ORs were calculated only among the cases admitted to the PICU.
†Children may have had >1 diagnosis.
‡Acute exacerbation of a chronic disease or new diagnosis.
