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Volume 17, Number 2—February 2011

Research

Possible Increased Pathogenicity of Pandemic (H1N1) 2009 Influenza Virus upon Reassortment

Eefje J.A. Schrauwen, Sander Herfst, Salin Chutinimitkul, Theo M. Bestebroer, Guus F. Rimmelzwaan, Albert D.M.E. Osterhaus, Thijs Kuiken, and Ron A.M. FouchierComments to Author 
Author affiliations: Author affiliation: National Influenza Centre and Erasmus Medical Center Department of Virology, Rotterdam, the Netherlands

Main Article

Table 1

Predominant virus genome composition upon in vitro selection of mixtures of pandemic (H1N1) 2009–seasonal (H1N1) and pandemic (H1N1)–seasonal (H3N2) influenza virus reassortants*

Replicates PB2 PB1 PA HA NP NA M NS
Pandemic (H1N1) 2009–seasonal (H1N1) 1 sH1 pH1 sH1 pH1 pH1 pH1 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H1N1) 2 sH1 pH1 sH1 pH1 pH1 pH1 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H1N1) 3 sH1 pH1 pH1 pH1 pH1 pH1 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H1N1) 4 pH1 pH1 pH1 pH1 pH1 pH1 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H3N2) 1 pH1 sH3 pH1 pH1 pH1 sH3 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H3N2) 2 pH1 pH1 pH1 pH1 pH1 sH3 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H3N2) 3 pH1 sH3 pH1 pH1 pH1 sH3 pH1 pH1
Pandemic (H1N1) 2009–seasonal (H3N2) 4 pH1 sH3 pH1 pH1 pH1 sH3 pH1 pH1

*PB, basic polymerase; PA, acidic polymerase; HA, hemagglutinin; NP, nucleoprotein; NA, neuraminidase; M, matrix; NS, nonstructural; sH1, seasonal influenza A virus (H1N1); pH1, pandemic (H1N1) 2009 virus; sH3, seasonal influenza A (H3N2) virus.

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