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Volume 17, Number 2—February 2011

Letter

New Delhi Metallo-β-Lactamase, Ontario, Canada

Nathalie Tijet, David C. Alexander, David Richardson, Olga Lastovetska, Donald E. Low, Samir N. Patel, and Roberto G. MelanoComments to Author 
Author affiliations: Author affiliations: Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada (N. Tijet, D.C. Alexander, O. Lastovetska, D.E. Low, S.N. Patel, R.G. Melano); University of Toronto, Toronto (D.C. Alexander, O. Lastovetska, D.E. Low, S.N. Patel); William Osler Health Centre, Brampton Civic Hospital, Brampton, Ontario, Canada (D. Richardson); Mount Sinai Hospital, Toronto (D.E. Low, R.G. Melano)

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Table

Antibacterial drug susceptibility profiles and resistance genes of Klebsiella pneumoniae GN529 clinical isolate and its Escherichia coli transconjugant, Ontario, Canada, 2010*

Antibacterial drug or gene
MIC, μg/mL
Kpn GN529
Eco J529
Eco J53
Ampicillin >256 >256 6
Cefoxitin >256 >256 8
Ceftazidime >256 >256 0.19
Cefotaxime >256 >256 0.094
Cefepime 48 48 0.064
Ertapenem 32 12 0.008
Meropenem >32 4 0.023
Imipenem >32 32 0.38
Amikacin >256 >256 1.5
Gentamicin >256 >256 1.5
Tobramycin >256 >256 1
Ciprofloxacin >32 0.012 0.012
Tetracycline >16 0.78 1
Tigecycline 1 ND ND
Nitrofurantoin >512 ND ND
Colistin 0.5 ND ND
Co-trimoxazole
4/76
ND
ND
PCR† and sequencing
blaNDM-1 + + ND
blaCTX-M-15 + ND
blaSHV-12 + + ND
blaSHV-11 + ND
blaOXA-1 + ND
blaTEM-1 + ND
armA + + ND

*Kpn, Klebsiella pneumoniae; Eco J529, Escherichia coli transconjugant strain; Eco J53, recipient E. coli J53; ND, not determined.
†PCR screening included blaTEM, blaSHV, blaOXA-1-like, blaCTX-M groups 1, 2, and 9, blaVEB, blaPER, blaGES, blaOXA-48-like, blaIMP, blaVIM, blaKPC, blaNDM-1, and 6 groups of blaAmpC genes.

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