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Volume 17, Number 3—March 2011

Research

Swine Influenza Virus Antibodies in Humans, Western Europe, 2009

Nancy A. Gerloff, Jacques R. Kremer, Emilie Charpentier, Aurélie Sausy, Christophe M. Olinger, Pierre Weicherding, John Schuh, Kristien Van Reeth, and Claude P. MullerComments to Author 
Author affiliations: Author affiliations: Centre de Recherche Public de la Santé/Laboratoire National de Santé, Luxembourg, Grand-Duchy of Luxembourg (N.A. Gerloff, J.R. Kremer, E. Charpentier, A. Sausy, C.P. Muller); Laboratoires Réunis, Junglinster, Luxembourg (C.M. Olinger, J. Schuh); Health Directorate, Luxembourg (P. Weicherding); Ghent University, Ghent, Belgium (K. Van Reeth)

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Table 3

Neutralizing antibody reactivity against 3 influenza viruses in swine workers and controls, Luxembourg, 2008–2009*

Virus (strain) and cutoff value Swine workers,
no. (%; 95% CI), n = 211 Controls,
no. (%; 95% CI), n = 224 p value
Pandemic (H1N1) 2009 (A/Luxembourg/43/2009)
>10 46 (21.8; 16.8–27.9)† 23 (10.3); 6.9–14.9)‡ 0.001§
>20 37 (17.5; 13–23.2)† 16 (7.1; 4.4–11.3)‡ 0.001§
>40 31 (14.7; 10.6–20.1) 12 (5.4; 3.1–9.1) 0.002§
>80 14 (6.6; 4–10.8) 4 (1.8; 0.7–4.5) 0.02§
>160 6 (2.8; 1.3–6.06) 0 (0; 0–1.2) 0.033¶
>320
5 (2.4; 1–5.4)
0 (0; 0–1.2)
0.061¶
Avian-like SIV (H1N1) (A/swine/Belgium/1/98)
>10 66 (31.3) 25.4–37.8) 59 (26.3; 21–32.5) 0.289§
>20 57 (27; 21.5–33.4) 38 (17; 12.6–22.4) 0.015§
>40 39 (18.5; 13.8–24.3) 12 (5.4; 3.1–9.1) <0.001§
>80 21 (10; 6.6–14.7) 4 (1.8; 0.7–4.5) <0.001§
>160 9 (4.3; 2.3–7.9) 1 (0.4; 0.1–2.5) 0.019¶
>320
4 (1.9; 0.7–4.8)
1 (0.4; 0.1–2.5)
0.331¶
Seasonal influenza (H1N1) (A/Luxembourg/572/2008)#
>10 183 (87.1; 83–91.9) 132 (59.7; 53.2–66) <0.001§
>20 125 (59.5; 52.8–65.9) 76 (34.4; 28.4–40.9) <0.001§
>40 61 (29; 23.3–35.5) 39 (17.6; 13.2–23.2) 0.007§
>80 21 (10; 6.6–14.9) 17 (7.7; 4.8–12) 0.500§
>160 14 (6.7; 3.9–11) 7 (3.2; 1.4–6.5) 0.144§
>320 11 (5.2; 2.9–9.2) 4 (1.8; 0.5–4.7) 0.093§

*Values are no. persons with antibodies. CI, confidence interval; SIV, swine influenza virus. Boldface indicates significance (p<0.05).
†p<0.05 when compared with swine workers against avian-like SIV (H1N1) of the same titer cutoff.
‡p<0.003 when compared with swine workers against avian-like SIV (H1N1) of the same titer cutoff.
§χ2 test on 2-way table.
z-test.
#Data for 210 swine workers, 221 controls.

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