Volume 17, Number 3—March 2011
Multidrug-Resistant Genotypes of Plasmodium falciparum, Myanmar
|Gene||Haplotype||Codon†||Haplotype prevalence,‡ %
|2007, n = 41||2008, n = 40||2009, n = 36|
|Pfdhfr (51, 59, 108, 164)
|Pfdhps (436, 437, 540, 581)||Wild-type||SAKA||2.4||–||2.8|
*Pfdhfr, Plasmodium falciparum dihydrofolate reductase; Pfdhps, P. falciparum dihydropoteroate synthase; –, no such haplotype detected.
†Codons in boldface indicate mutated amino acids.
‡χ2 test was performed with all data points of the 2 genes, which showed that overall haplotype prevalence differed significantly between the years (χ2 test, p<0.0001, χ2 = 76.49, df = 28). Major dhfr and dhps haplotypes were individually compared. For each haplotype (in the same row), the labeling by different letters denotes significant difference between the years (χ2 test, p<0.05).
1These authors contributed equally to this article.
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