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Volume 17, Number 3—March 2011

Research

Monitoring and Characterization of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Japan, 2009–2010

Makoto Ujike, Miho Ejima, Akane Anraku, Kozue Shimabukuro, Masatsugu Obuchi, Noriko Kishida, Xu Hong, Emi Takashita, Seiichiro Fujisaki, Kazuyo Yamashita, Hiroshi Horikawa, Yumiko Kato, Akio Oguchi, Nobuyuki Fujita, Masato Tashiro, Takato OdagiriComments to Author , and the Influenza Virus Surveillance Group of Japan
Author affiliations: Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (M. Ujike, M. Ejima, A. Anraku, K. Shimabukuro, M. Obuchi, N. Kishida, X. Hong, E. Takashita, S. Fujisaki, K. Yamashita, M. Tashiro, T. Odagiri); National Institute of Technology and Evaluation, Tokyo (H. Horikawa, Y. Kato, A. Oguchi, N. Fujita)

Main Article

Table A1

Amino acid difference(s) of OR (n = 61) from OS (n = 190) pandemic (H1N1) 2009 virus consensus sequences in neuraminidase protein*

Strains Amino acid difference(s) of neuraminidase protein
15
16
34
40
41
43
80
82
83
85
86
95
98
106
138
154
166
195
222†
234
248
257
269
275
286
289
382
386
416
430
452
M T I L G Q V S V L A S A I A P V I A V D R M Y S T G N D R T
A/Niigata/1459/2009 E‡ Y/H§
A/Hiroshima/590/2009 E Y
A/Shizuoka-C/270/2009 E Y
A/Tochigi/471/2009 E Y
A/Yokohama/1340/2009 E Y
A/Niigata/10016/2009 E R Y
A/Aichi/1210/2009 P Y/H
A/Kobe/92495/2009 P Y
A/Mie/100/2009 P Y
A/Saitama/374/2009 P Y/H
A/Wakayama/318/2009 P Y/H
A/Yamaguchi/248/2009 P Y
A/Yamanashi/847/2009 P Y
A/Yokohama/1563/2009 P Y
A/Fukuoka/1/2010 M P Y
A/Yamagata/29/2010 P T N Y
A/Wakayama-C/1/2010 P T Y/H
A/Niigata/10019/2009 P A Y
A/Osaka/180/2009 N Y
A/Oita/126/2009 I V N Y G
A/Shizuoka-C/172/2009 G V N Y
A/Osaka/2191/2009 I Y
A/Tochigi/609/2009 I Y/H
A/Tochigi/612/2009 I Y
A/Hokkaido/256/2009 Y/H N
A/Shizuoka-C/247/2009 Y N
A/Wakayama/291/2009 Y N
A/Shiga/45/2009 F Y N
A/Sapporo/576/2009 S V Y N
A/Yokohama/1538/2009 V Y/H N
A/FUKUI/159/2009 Y E N
A/Osaka/2024/2009 I Y
A/Shiga/43/2009 V Y/H
A/Aichi/1166/2009 K Y
A/Sapporo/31/2010 M Y
A/Shimane/1062/2009 F Y/H
A/Saitama/396/2009 T Y
A/Shiga/61/2009 I Y
A/Shizuoka/1380/2009 K Y
A/Hyogo/2003/2009 K Y I
A/Osaka/2143/2009 Y I
A/Mie/137/2009 Y/H D
A/Tochigi/373/2009 Y/H D
A/Aichi/1019/2009 Y Q
A/Chiba/1017/2009 Y
A/Fukushima/452/2009 Y
A/Iwate/3/2009 Y
A/Kitakyusyu/4/2010 Y
A/Miyazaki/111/2009 Y
A/Niigata/1233/2009 Y
A/Niigata/1234/2009 Y
A/Niigata-C/186/2009 Y
A/Saitama/408/2009 Y
A/Saitama-C/88/2009 Y
A/Sapporo/190/2009 Y
A/Shimane/188/2009 Y
A/Tokushima/2/2009 Y
A/Tottori/225/2009 Y
A/Yamagata/534/2009 Y
A/Yamaguchi/22/2009 Y
A/Yokohama/1394/2009























Y/H







*OR, oseltamivir resistant; OS, oseltamivir susceptible.
†Recent OR seasonal influenza A (H1N1) isolates have R222Q and V234M mutations that would restore viral fitness (23).
‡Of 190 pandemic (H1N1) 2009 virus isolates, G41E, S82P, D248N, M269I, and D416N were observed from 4, 10, 27, 0, and 17 OS pandemic (H1N1) 2009 virus isolates, respectively.
§Mixed population of H275 and Y275.

Main Article

1Members of the Influenza Virus Surveillance Group of Japan are listed at the end of this article.

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