Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 17, Number 3—March 2011
Research

Monitoring and Characterization of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus, Japan, 2009–2010

Makoto Ujike, Miho Ejima, Akane Anraku, Kozue Shimabukuro, Masatsugu Obuchi, Noriko Kishida, Xu Hong, Emi Takashita, Seiichiro Fujisaki, Kazuyo Yamashita, Hiroshi Horikawa, Yumiko Kato, Akio Oguchi, Nobuyuki Fujita, Masato Tashiro, Takato OdagiriComments to Author , and the Influenza Virus Surveillance Group of Japan
Author affiliations: Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (M. Ujike, M. Ejima, A. Anraku, K. Shimabukuro, M. Obuchi, N. Kishida, X. Hong, E. Takashita, S. Fujisaki, K. Yamashita, M. Tashiro, T. Odagiri); National Institute of Technology and Evaluation, Tokyo (H. Horikawa, Y. Kato, A. Oguchi, N. Fujita)

Main Article

Table A1

Amino acid difference(s) of OR (n = 61) from OS (n = 190) pandemic (H1N1) 2009 virus consensus sequences in neuraminidase protein*

Strains Amino acid difference(s) of neuraminidase protein
15
 16
 34
 40
 41
 43
 80
 82
 83
 85
 86
 95
 98
 106
 138
 154
 166
 195
 222†
 234
 248
 257
 269
 275
 286
 289
 382
 386
 416
 430
 452
M T I L G Q V S V L A S A I A P V I A V D R M Y S T G N D R T
A/Niigata/1459/2009 E‡ Y/H§
A/Hiroshima/590/2009 E Y
A/Shizuoka-C/270/2009 E Y
A/Tochigi/471/2009 E Y
A/Yokohama/1340/2009 E Y
A/Niigata/10016/2009 E R Y
A/Aichi/1210/2009 P Y/H
A/Kobe/92495/2009 P Y
A/Mie/100/2009 P Y
A/Saitama/374/2009 P Y/H
A/Wakayama/318/2009 P Y/H
A/Yamaguchi/248/2009 P Y
A/Yamanashi/847/2009 P Y
A/Yokohama/1563/2009 P Y
A/Fukuoka/1/2010 M P Y
A/Yamagata/29/2010 P T N Y
A/Wakayama-C/1/2010 P T Y/H
A/Niigata/10019/2009 P A Y
A/Osaka/180/2009 N Y
A/Oita/126/2009 I V N Y G
A/Shizuoka-C/172/2009 G V N Y
A/Osaka/2191/2009 I Y
A/Tochigi/609/2009 I Y/H
A/Tochigi/612/2009 I Y
A/Hokkaido/256/2009 Y/H N
A/Shizuoka-C/247/2009 Y N
A/Wakayama/291/2009 Y N
A/Shiga/45/2009 F Y N
A/Sapporo/576/2009 S V Y N
A/Yokohama/1538/2009 V Y/H N
A/FUKUI/159/2009 Y E N
A/Osaka/2024/2009 I Y
A/Shiga/43/2009 V Y/H
A/Aichi/1166/2009 K Y
A/Sapporo/31/2010 M Y
A/Shimane/1062/2009 F Y/H
A/Saitama/396/2009 T Y
A/Shiga/61/2009 I Y
A/Shizuoka/1380/2009 K Y
A/Hyogo/2003/2009 K Y I
A/Osaka/2143/2009 Y I
A/Mie/137/2009 Y/H D
A/Tochigi/373/2009 Y/H D
A/Aichi/1019/2009 Y Q
A/Chiba/1017/2009 Y
A/Fukushima/452/2009 Y
A/Iwate/3/2009 Y
A/Kitakyusyu/4/2010 Y
A/Miyazaki/111/2009 Y
A/Niigata/1233/2009 Y
A/Niigata/1234/2009 Y
A/Niigata-C/186/2009 Y
A/Saitama/408/2009 Y
A/Saitama-C/88/2009 Y
A/Sapporo/190/2009 Y
A/Shimane/188/2009 Y
A/Tokushima/2/2009 Y
A/Tottori/225/2009 Y
A/Yamagata/534/2009 Y
A/Yamaguchi/22/2009 Y
A/Yokohama/1394/2009
Y/H
*OR, oseltamivir resistant; OS, oseltamivir susceptible.
†Recent OR seasonal influenza A (H1N1) isolates have R222Q and V234M mutations that would restore viral fitness (23).
‡Of 190 pandemic (H1N1) 2009 virus isolates, G41E, S82P, D248N, M269I, and D416N were observed from 4, 10, 27, 0, and 17 OS pandemic (H1N1) 2009 virus isolates, respectively.
§Mixed population of H275 and Y275.

Main Article

1Members of the Influenza Virus Surveillance Group of Japan are listed at the end of this article.

Page created: July 25, 2011
Page updated: July 25, 2011
Page reviewed: July 25, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external