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Volume 17, Number 3—March 2011

Letter

Mycobacterium mageritense Pulmonary Disease in Patient with Compromised Immune System

R. Gordon HuthComments to Author , Barbara A. Brown-Elliott, and Richard J. Wallace
Author affiliations: Author affiliations: University of Texas Southwestern Residency Programs, Austin, Texas, USA (R.G. Huth); University of Texas Health Science Center, Tyler, Texas, USA (B.A. Brown-Elliott, R.J. Wallace, Jr.)

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Table

In vitro activity of 23 isolates of Mycobacterium mageritense, United States, 2009*

Antimicrobial agent
 No. isolates tested
 MICs of current isolate, μg/mL
 Intermediate breakpoint, μg/mL
 MIC range, μg/mL
 MIC50, μg/mL
 MIC90, μg/mL
 % S/I
Amikacin 23 8 32 <1–32 16 32 100
Cefoxitin 23 16 32–64 <8–256 32 64 91
Ciprofloxacin 23 0.25 2 <0.25–0.5 0.25 0.5 100
Clarithromycin† 23 8 4 1–>64 >32 >64 4
Doxycycline 22 1 2–8 0.25–>64 8 >32 50
Imipenem 22 4 8 <0.5–8 2 4 100
Linezolid 22 4 16 <2–16 4 8 100
Sulfamethoxazole 21 4 32 <2–32 8 32 100
Trimethoprim/sulfamethoxazole 6 1/19 2/38‡ <0.25/4.8– 2/38 0.5/9.5 2/38 100
Tobramycin 23 <2 8 2–64 >16 >32 30
Tigecycline 5 0.12 –§ <0.03–0.12 0.06 0.12 NA

*Includes 6 isolates previously reported (2). S, susceptible; I, intermediate; NA, not available.
†Three days’ incubation.
‡Proposed breakpoint (7).
§No Clinical and Laboratory Standards Institute breakpoints established for tigecycline.

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