Neisseria meningitidis Strain of Unknown Serogroup, China
Haijian Zhou, Zhujun Shao , Qian Li, Li Xu, Jiang Wu, Biao Kan, and Jianguo Xu
Author affiliations: Author’s affiliation: National Institute for Communicable Disease Control and Prevention, Beijing, People’s Republic of China (H. Zhou, Z. Shao, L. Xu, B. Kan, J. Xu); State Key Laboratory for Infectious Disease Prevention and Control, Beijing (H. Zhou, Z. Shao, Q. Li, B. Kan, J. Xu); Beijing Center for Disease Prevention and Control, Beijing (J. Wu)
Figure. Genetic basis for the Neisseria meningitidis strain that cannot be placed in a known serogroup. A predicted slipped-strand mispairing occurred within synD, which encodes the serogroup B sialyltransferase. In wild-type N. meningitidis serogroup B (MC58), the synD polyC tract contains 7 C residues, and capsule is expressed. When an insertion (as in isolate 100924) of 1 C residue occurs, a result of local denaturation and mispairing followed by replication or repair, a premature stop codon is generated, and the capsule is not expressed.
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