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Volume 17, Number 3—March 2011

Research

Targeted Drug-Resistance Testing Strategy for Multidrug-Resistant Tuberculosis Detection, Lima, Peru, 2005–2008

Gustavo E. Velásquez, Martin Yagui, J. Peter Cegielski, Luis Asencios, Jaime Bayona, Cesar Bonilla, Hector O. Jave, Gloria Yale, Carmen Suárez, Sidney Atwood, Carmen C. Contreras, and Sonya S. ShinComments to Author 
Author affiliations: Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (G.E. Velásquez, S. Atwood, S.S. Shin); Instituto Nacional de Salud, Lima, Peru (M. Yagui, L. Asencios); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.P. Cegielski); Socios En Salud, Lima (J. Bayona, C.C. Conteras, S.S. Shin); Partners In Health, Boston (S.S. Shin); Dartmouth College, Hanover, New Hampshire, USA (J. Bayona); Ministerio de Salud del Perú, Lima (C. Bonilla, H.O. Jave); Dirección de Salud V Lima Ciudad, Lima (G. Yale); Dirección de Salud IV Lima Este, Lima (C. Suárez)

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Table 3

Prevalence estimates of TB drug resistance from national and regional surveillance data, and proportion of drug resistance in study cohort, Lima, Peru, 2005–2008*

Cohort Total no. patients No. (%) susceptible to INH and RIF No. (%) monoresistant to INH or RIF No. (%)
MDR TB
Peruvian NTP drug-resistance surveillance, national data (21)
All TB patients 2,167 1,829 (84.4) 158 (7.3) 180 (8.3)
New TB patients 1,816 1,597 (87.9) 124 (6.8) 95 (5.2)
Previously treated patients
351
232 (66.1)
34 (9.7)
85 (24.2)
Peruvian NTP drug-resistance surveillance, regional data corresponding to study area†
All TB patients 580 467 (80.5) 41 (7.1) 72 (12.4)
New TB patients 476 396 (83.2) 33 (6.9) 47 (9.9)
Previously treated patients
104
71 (68.3)
8 (7.7)
25 (24.0)
Study cohort
All TB patients 1,241 661 (53.3) 161 (13.0) 419 (33.8)
New TB patients 612 333 (54.4) 84 (13.7) 195 (31.9)
Previously treated patients
629
328 (52.2)
77 (12.2)
224 (35.6)
Study cohort, smear-positive samples only
All TB patients 1,114 581 (52.2) 143 (12.8) 390 (35.0)
New TB patients 531 278 (52.4) 73 (13.8) 180 (33.9)
Previously treated patients 583 303 (52.0) 70 (12.0) 210 (36.0)

*TB, tuberculosis; INH, isoniazid; RIF, rifampin; MDR, multidrug resistant; NTP, National Tuberculosis Control Program.
†Ministerio de Salud, Peru, unpub. data.

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