TY - JOUR AU - Pirisinu, Laura AU - Migliore, Sergio AU - Di Bari, Michele Angelo AU - Esposito, Elena AU - Baron, Thierry AU - D’Agostino, Claudia AU - De Grossi, Luigi AU - Vaccari, Gabriele AU - Agrimi, Umberto AU - Nonno, Romolo T1 - Molecular Discrimination of Sheep Bovine Spongiform Encephalopathy from Scrapie T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 4 SP - 695 SN - 1080-6059 AB - Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE. KW - Prions KW - transmissible spongiform encephalopathy KW - scrapie KW - bovine spongiform encephalopathy KW - BSE KW - CH1641 KW - sheep KW - Western blot KW - dispatch DO - 10.3201/eid1704.101215 UR - https://wwwnc.cdc.gov/eid/article/17/4/10-1215_article ER - End of Reference