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Volume 17, Number 4—April 2011


Drug-Resistant Pandemic (H1N1) 2009, South Korea1

Soo Youn Shin, Chun Kang, Jin Gwack, Joon Hyung Kim, Hyun Su Kim, Young A Kang, Ha Gyung Lee, Jin Seok Kim, Jong-Koo Lee, and Sung-Han KimComments to Author 
Author affiliations: Author affiliations: Korea Centers for Disease Control and Prevention, Seoul, South Korea (S.Y. Shin, C. Kang, J. Gwack, J.H. Kim, H.S. Kim, Y.A. Kang, H.G. Lee, J.S. Kim, J.-K. Lee); University of Ulsan College of Medicine, Seoul (S.-H. Kim)

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Characteristics of 11 patients with oseltamivir-resistant pandemic (H1N1) 2009, South Korea*

Characteristic Value
Median age, y (range) 5 (1–63)
Male sex
No. at high risk for influenza-related complications
<59 mo of age 6
Chronic medical disorders 9
Neurologic 3
Hematologic 3
Metabolic, including diabetes† 2
Pulmonary, including asthma 1
Renal† 1
Cardiovascular, excluding hypertension 0
Hepatic disorder 0
Median days from symptom onset to viral isolation (range) 2 (0–9)
Median days from symptom onset to development of resistance
No. hospitalized 11
Hospitalization duration, d, median (range) 15 (6–53)
Symptom duration, d, median (range)
17 (6–22)
No. with respiratory illness related to influenza 11
Viral pneumonia 6
Secondary bacterial pneumonia 2
Secondary bacterial pneumonia and acute respiratory distress syndrome
Reasons for requesting drug-resistance testing
Treatment failure 9
Prolonged viral shedding
No. with co-infections§
Cured 8
Died¶ 3

*Specimens were obtained from oropharyngeal (n = 7) and nasopharyngeal (n = 2) swabs, nasopharyngeal washings (n = 1), and brochoalveolar lavage fluid (n = 1).
†One patient had diabetes and chronic renal failure.
‡Patients who had underlying diseases such as HIV infection, malignancy, liver cirrhosis, or chronic renal failure, or patients receiving immunosuppressive treatment.
§Carbapenem-resistant Pseudomonas aeruginosa (patient 3), carbapenem-resistant Acinetobacter baumanii (patient 4), and penicillin-susceptible Streptococcus pneumonia (patient 10).
¶Of the 3 patients, 1 was infected with carbapenem-resistant P. aeruginosa (patient 3) and 1 was infected with carbapenem-resistant A. baumanii (patient 4).

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1Presented in part at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2010 Sep 12–15; Boston, Massachusetts, USA (late-breaker posters session, abstract V-448c).