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Volume 17, Number 4—April 2011

Dispatch

Drug-Resistant Pandemic (H1N1) 2009, South Korea1

Soo Youn Shin, Chun Kang, Jin Gwack, Joon Hyung Kim, Hyun Su Kim, Young A Kang, Ha Gyung Lee, Jin Seok Kim, Jong-Koo Lee, and Sung-Han KimComments to Author 
Author affiliations: Author affiliations: Korea Centers for Disease Control and Prevention, Seoul, South Korea (S.Y. Shin, C. Kang, J. Gwack, J.H. Kim, H.S. Kim, Y.A. Kang, H.G. Lee, J.S. Kim, J.-K. Lee); University of Ulsan College of Medicine, Seoul (S.-H. Kim)

Main Article

Table

Characteristics of 11 patients with oseltamivir-resistant pandemic (H1N1) 2009, South Korea*

Characteristic Value
Median age, y (range) 5 (1–63)
Male sex
6
No. at high risk for influenza-related complications
<59 mo of age 6
Chronic medical disorders 9
Neurologic 3
Hematologic 3
Metabolic, including diabetes† 2
Pulmonary, including asthma 1
Renal† 1
Cardiovascular, excluding hypertension 0
Hepatic disorder 0
Immunocompromised‡
5
Median days from symptom onset to viral isolation (range) 2 (0–9)
Median days from symptom onset to development of resistance
8
No. hospitalized 11
Hospitalization duration, d, median (range) 15 (6–53)
Symptom duration, d, median (range)
17 (6–22)
No. with respiratory illness related to influenza 11
Viral pneumonia 6
Secondary bacterial pneumonia 2
Secondary bacterial pneumonia and acute respiratory distress syndrome
1
Reasons for requesting drug-resistance testing
Treatment failure 9
Prolonged viral shedding
2
No. with co-infections§
3
Outcome
Cured 8
Died¶ 3

*Specimens were obtained from oropharyngeal (n = 7) and nasopharyngeal (n = 2) swabs, nasopharyngeal washings (n = 1), and brochoalveolar lavage fluid (n = 1).
†One patient had diabetes and chronic renal failure.
‡Patients who had underlying diseases such as HIV infection, malignancy, liver cirrhosis, or chronic renal failure, or patients receiving immunosuppressive treatment.
§Carbapenem-resistant Pseudomonas aeruginosa (patient 3), carbapenem-resistant Acinetobacter baumanii (patient 4), and penicillin-susceptible Streptococcus pneumonia (patient 10).
¶Of the 3 patients, 1 was infected with carbapenem-resistant P. aeruginosa (patient 3) and 1 was infected with carbapenem-resistant A. baumanii (patient 4).

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1Presented in part at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2010 Sep 12–15; Boston, Massachusetts, USA (late-breaker posters session, abstract V-448c).

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