TY - JOUR AU - Roest, Hendrik I.J. AU - Ruuls, Robin C. AU - Tilburg, Jeroen J.H.C. AU - Nabuurs-Franssen, Marrigje H. AU - Klaassen, Corné H.W. AU - Vellema, Piet AU - van den Brom, René AU - Dercksen, Daan AU - Wouda, Willem AU - Spierenburg, Marcel A.H. AU - van der Spek, Arco N. AU - Buijs, Rob AU - de Boer, Albert G. AU - Willemsen, Peter Th.J. AU - van Zijderveld, Fred G. T1 - Molecular Epidemiology of Coxiella burnetii from Ruminants in Q Fever Outbreak, the Netherlands T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 4 SP - 668 SN - 1080-6059 AB - Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii–positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands. KW - Q fever KW - Coxiella burnetii KW - molecular epidemiology KW - bacteria KW - zoonoses KW - goat KW - sheep KW - cattle KW - the Netherlands KW - research DO - 10.3201/eid1704.101562 UR - https://wwwnc.cdc.gov/eid/article/17/4/10-1562_article ER - End of Reference