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Volume 17, Number 5—May 2011

Research

Plasmodium knowlesi Malaria in Children

Bridget E. BarberComments to Author , Timothy William, Mohammad Jikal, Jenarun Jilip, Prabakaran Dhararaj, Jayaram Menon, Tsin W. Yeo, and Nicholas M. Anstey
Author affiliations: Author affiliations: Menzies School of Health Research, Darwin, Northern Territory, Australia (B.E. Barber, T.W. Yeo, N.M. Anstey); Charles Darwin University, Darwin, Northern Territory (B.E. Barber, T.W. Yeo, N.M. Anstey); Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia (B.E. Barber, T. William, J. Menon); Sabah Department of Health, Kota Kinabalu (T. William, M. Jikal, J. Jilip, J. Menon); Kudat District Hospital, Kudat, Sabah, Malaysia (P. Dhararaj); Royal Darwin Hospital, Darwin (T.W. Yeo, N.M. Anstey)

Main Article

Table 1

Demographic data, clinical features of infection, and laboratory values in 14 cases of Plasmodium falciparum malaria and 16 cases of PCR-confirmed P. knowlesi malaria in children, Kudat, Malaysia, January 1–November 30, 2009*

Characteristic P. knowlesi, n =16 P. falciparum, n =14 p value
Age, y
Mean (SD) 8.9 (2.5) 5.4 (3.2) 0.002
Range
4–14
0.75–11

Male sex, no. (%)
8 (50)
7 (50)
1.00
Living in Banggi, no. (%)
0 (0)
10 (71.4)
<0.001
Duration of fever, d, median (IQR)
4 (3–6)
6.5 (4–7)
0.12
Examination findings at admission
Temperature, oC, median (IQR) 37.9 (37.0–39.1) 37.0 (37.0–37.4) 0.07
Heart rate, beats/min, mean (SD) 110 (24) 119 (15) 0.24
Respiratory rate, beats/min, mean (SD) 27.8 (3.9) 32 (3.8) 0.01
Systolic blood pressure, mm Hg, mean (SD)
105 (8.3)
98 (11.2)
0.06
Laboratory results
Hemoglobin d 0, g/dL, median (IQR) 10.7 (10.0–11.4) 8.5 (6.1–10.5) 0.001
Hemoglobin minimum level, g/dL, median (IQR) 9.7 (8.4–10.2) 7.15 (6.1–9.3) 0.035
Day of hemoglobin minimum level, mean (SD) 2.6 (1.03) 1.5 (1.3) 0.022
Lymphocyte count d 0, × 103/µL, median (IQR) 2.0 (1.7–2.3) 2.5 (2.0–4.6) 0.09
Lymphocyte minimum level, × 103/µL, median (IQR) 1.6 (1.3–2.2) 2.4 (1.9–3.9) 0.01
Day of lymphocyte minimum level, median (IQR) 1 (0–1) 1.5 (0–3) 0.19
Thrombocyte count d 0, × 103/µL, median (IQR) 89.5 (72.0–118.5) 171.5 (98–271) 0.038
Thrombocyte count minimum level, × 103/µL, median (IQR) 76.5 (68.5–110.0) 156 (98–227) 0.014
Day of thrombocyte count minimum level, median (IQR) 1 (1–1) 0.5 (0–2) 0.67

*IQR, interquartile range. Boldface indicates statistical significance.

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