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Volume 17, Number 5—May 2011

Research

Plasmodium knowlesi Malaria in Children

Bridget E. BarberComments to Author , Timothy William, Mohammad Jikal, Jenarun Jilip, Prabakaran Dhararaj, Jayaram Menon, Tsin W. Yeo, and Nicholas M. Anstey
Author affiliations: Author affiliations: Menzies School of Health Research, Darwin, Northern Territory, Australia (B.E. Barber, T.W. Yeo, N.M. Anstey); Charles Darwin University, Darwin, Northern Territory (B.E. Barber, T.W. Yeo, N.M. Anstey); Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia (B.E. Barber, T. William, J. Menon); Sabah Department of Health, Kota Kinabalu (T. William, M. Jikal, J. Jilip, J. Menon); Kudat District Hospital, Kudat, Sabah, Malaysia (P. Dhararaj); Royal Darwin Hospital, Darwin (T.W. Yeo, N.M. Anstey)

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Table 2

Malaria treatment according to Plasmodium species and response to treatment in children, Kudat, Malaysia, January 1–November 30, 2009*

Species and treatment regimen No. (%) patients Days until negative smear†
P. knowlesi, n = 16
3 days CQ/PQ 13 (81) 2 (2–3, 1–5)
Oral Q 2 (13) 2, 2
IV Q 1 (6) 2
All

2 (2–3, 1–5)
P. falciparum, n = 14
3 days CQ/PQ → oral Q 2 (14) 5, 5
Oral Q → AL 1 (7) 3
SP/PQ → AM 1 (7) 8
SP/PQ 2 (14) 1, 2
SP/PQ → CQ/Q → AL 1 (7) 3
SP/PQ → CQ/IV Q → AL 1 (7) 5
SP/PQ → CQ/IV Q → oral Q 1 (7) 3
SP/PQ → oral Q → IV Q → oral Q 1 (7) 16
IV Q → oral Q 2 (14) 1, 10
IV Q → oral Q/PQ 1 (7) 11
Oral Q/PQ → AM 1 (7) 10
All 5 (3–10, 1–16)‡

*IQR, interquartile range; CQ, chloroquine; PQ, primaquine; Q, quinine; IV, intravenous; AL, artemether/lumefantrine; SP, sulfamethoxazole/pyrimethamine; AM, artesunate/mefloquine.
†Values are mean (IQR, range) by category or days by patient.
‡p value = 0.009 for days until negative smear for P. falciparum vs. P. knowlesi.

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