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Volume 17, Number 5—May 2011

Dispatch

Chikungunya Virus, Southeastern France

Marc GrandadamComments to Author , Valérie Caro, Sébastien Plumet, Jean-Michel Thiberge, Yvan Souarès, Anna-Bella Failloux, Hugues J. Tolou, Michel Budelot, Didier Cosserat, Isabelle Leparc-Goffart, and Philippe Desprès
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (M. Grandadam, V. Caro, J.-M. Thiberge, A.-B. Failloux, P. Desprès); Institut de Recherche Biomédicale des Armées, Marseille, France (S. Plumet, H.J. Tolou, I. Leparc-Goffart); Institut de Veille Sanitaire, Saint-Maurice, France (Y. Souarès); Private Consulting Rooms, Saint-Raphaël, France (M. Budelot, D. Cosserat)

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Table

Relevant amino acid substitutions identified between France/2010 CHIKV isolates (autochthonous and imported cases) versus a selection of CHIKV strains*

Strain
Country
Year
Protein position
E2-60
E2-162
E2-211
E2-264†
E1-211
E1-226
E1-269
E1-284
France/2010/1630/human/ imported (a) France (India) 2010 D A T A E A V E
France/2010/1909/human/ autochthonous (a) France 2010 D A T A E A V E
22833 (a) Côte d'Ivoire 1990 D A I V K A M D
CHIK31 (a) India 2006 D A T V K A V E
05209 (a) Seychelles 2005 D A T V K A V E
0561 (a) Réunion 2005 D A T V K A V E
0649 (a) Réunion 2005 D A T V K V V E
DHS4263-Calif-AB (a) California (India) 2006 D A T V K A V E
IND-GJ53 (a) India 2006 D A T V K A V E
IND-KR52 (a) India 2007 D A T V K V V E
ITA07-RA1 (a) Italy 2007 D A T V K V V E
KEN-Lamu-Oct04-KPA15 (a) Kenya 2004 D A T V K A V E
KEN-Mom-Jul04-33 (a) Kenya 2004 D A T V K A V E
S27 (a) Tanzania 1952 D A I V K A M D
SGEHICHD13508 (a) Singapore 2008 D A T V K A V E
CHIK/Pt11201/SIN/2009 (a) France (Singapore) 2009 D A T V K V V E
SL-CK1 (a) Sri Lanka 2007 D A T V K A V E
SL-CR 3 (a) Sri Lanka 2007 D A T V K A V E
Nagpur (India) 653496 (b) India 2003 D A T V E A M D
CHIK/Pt11352/INDO/2009 (b) France (Indonesia) 2009 D A T V E A M D
s37997 (c) Senegal 1983 D A T V K A V D

*Molecular signatures were based on the analysis of complete amino acid sequence E2-6K-E1 (923 aa). The numbering of amino acid positions refers to the African isolate S27 (GenBank access no. AF369024). Residues in boldface indicate critical aa changes. Letters in parentheses after strain names refer to East/Central/South Africa (a), Asia (b) and West Africa (c) phylogroups. Country names in parentheses identify source of imported case. CHIKV, chikungunya virus.
†The amino acid substitution was unique to France/2010 CHIKV isolates.

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