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Volume 17, Number 6—June 2011

Research

Use of Antiviral Drugs to Reduce Household Transmission of Pandemic (H1N1) 2009, United Kingdom1

Richard G. PebodyComments to Author , Ross Harris, George Kafatos, Mary Chamberland, Colin Campbell, Jonathan S. Nguyen-Van-Tam, Estelle McLean, Nick Andrews, Peter J. White, Edward Wynne-Evans, Jon Green, Joanna Ellis, Tim Wreghitt, Sam Bracebridge, Chikwe Ihekweazu, Isabel Oliver, Gillian Smith, Colin Hawkins, Roland Salmon, Brian Smyth, Jim McMenamin, Maria Zambon, Nick F. Phin, and John M. Watson
Author affiliations: Author affiliations: Health Protection Agency, London, UK (R.G. Pebody, R. Harris, G. Kafatos, M. Chamberland, C. Campbell, J.S. Nguyen-Van-Tam, E. McLean, N. Andrews, P.J. White, E. Wynne-Evans, J. Green, J. Ellis, T. Wreghitt, S. Bracebridge, C. Ihekweazu, I. Oliver, G. Smith, C. Hawkins, M. Zambon, N. Phin, J.M. Watson); Imperial College, London (P.J. White); Public Health Wales, Cardiff, Wales, UK (R. Salmon); Public Health Agency Northern Ireland, Belfast, Northern Ireland (B. Smyth); Health Protection Scotland, Glasgow, Scotland (J. McMenamin)

Main Article

Table 6

Univariate and multivariate analysis of pandemic (H1N1) 2009 virus infection SAR for clinically confirmed cases of influenza-like illness, by gender, age group, and prophylaxis, United Kingdom, 2009*

Variable No. contacts† No. secondary
case-patients Univariate analysis
Multivariate analysis
SAR % ( 95% CI) p value‡ OR (95% CI) p value
Sex, n = 730
M 357 33 9.2 (6.7–12.7) 1.00, baseline
F
373
45
12.1 (7.9–18.1)
0.22

2.6 (1.4–4.9)
0.003
Age group, y
<16 204 38 18.6 (13.9–24.6) 7.8 (2.7–22.1)
16–49 371 32 8.6 (5.4–13.5) 2.7 (1.0–7.4)
>50
170
8
4.7 (2.2–9.8)
<0.001

1.00, baseline
<0.001
Prophylaxis, n = 573
No 129 56 43.4 (35.1–52.1) 1.0, baseline
Yes
444
18
4.1 (2.3–7.1)
<0.001

0.05 (0.02–0.09)
<0.001
Primary case-patient treatment
>48 h 445 55 12.4 (9.6–15.8) 1.0, baseline
<48 h
300
23
7.7 (4.7–12.2)
0.040

0.78 (0.42–1.48)
0.458
Total 745 78 10.5 (8.5–12.9)

*n = 745 except as indicated. Hosmer-Lemeshow goodness-of-fit test for multivariable model, p = 0.291. SAR, secondary attack rate; CI, confidence interval; OR, odds ratio.
†Excludes co-primary case-patients.
‡Indicates overall p value for differences by group.

Main Article

1Elements of this work were presented at the Health Protection Agency Annual Conference in 2009. An abstract was presented at the International Conference on Emerging Infectious Diseases, Atlanta, Georgia, USA, 2010.

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