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Volume 17, Number 6—June 2011

Dispatch

Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype

Marie Accou-Demartin, Valérie Gaborieau, Yajun Song, Philippe Roumagnac, Bruno Marchou, Mark Achtman, and François-Xavier WeillComments to Author 
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (M. Accou-Demartin, F.-X. Weill); Hôpital Purpan, Toulouse, France (V. Gaborieau, B. Marchou); University College Cork, Cork, Ireland (Y. Song, M. Achtman); Centre de Coopération International en Recherche Agronomique pour le Développement, Montpellier, France (P. Roumagnac)

Main Article

Table 1

Characteristics of the 674 Salmonella enterica serovar Typhi isolates belonging to subpopulations A, C, and D, France, 2007–2009*

Subpopulation
No. isolates
Nal MICs,† μg/mL
Cip MICs,† μg/mL QRDR mutation (no./no. tested)
MIC50
MIC90
Range
MIC50
MIC90
Range
A 554 4 4 1–8 0.008 0.025 0.002–0.08 WT (75/77)
gyrB Leu465 (2/77)
C 119 >256 >256 128–>256 0.25 0.5 0.06–0.5 gyrA Phe83 (24/44)
gyrA Tyr83 (12/44)
gyrA Asn87 (4/44)
gyrA Gly87 (2/44)
gyrA Phe83 and parE Asn420 (2/44)
D 1 >256 8 gyrA Phe83, gyrA Asn87, and parC Ile80

*Nal, nalidixic acid; Cip, ciprofloxacin; QRDR, quinolone resistance–determining region of the gyrA, gyrB, parC, and parE genes; WT, wild type.
†MICs of Nal and Cip were determined by Etest strips. MIC50, 50% below; MIC90, 90% below.

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