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Volume 17, Number 6—June 2011

Dispatch

Salmonella enterica Serotype Typhi with Nonclassical Quinolone Resistance Phenotype

Marie Accou-Demartin, Valérie Gaborieau, Yajun Song, Philippe Roumagnac, Bruno Marchou, Mark Achtman, and François-Xavier WeillComments to Author 
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (M. Accou-Demartin, F.-X. Weill); Hôpital Purpan, Toulouse, France (V. Gaborieau, B. Marchou); University College Cork, Cork, Ireland (Y. Song, M. Achtman); Centre de Coopération International en Recherche Agronomique pour le Développement, Montpellier, France (P. Roumagnac)

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Table 2

Characteristics of the 11 Salmonella enterica serovar Typhi isolates belonging to subpopulation B, France, 2007–2009

Isolate Year Geographic origin Antimicrobial drug resistance type Disk diffusion, mm
MIC, μg/mL
gyrB Haplotype PFGE
Nal Cip Nal Cip
97-5123 1997 Unknown CipDS 18 [I] 28 [S] 8 [S/S] 0.125 [S/S] Tyr464 Non-H58 X8
02-2759 2002 India CipDS 19 [I] 26 [S] 4 [S/S] 0.125 [S/S] Phe464 H58 X2
05-1578 2005 India Pansusceptible 18 [I] 28 [S] 8 [S/S] 0.047 [S/S] Asp466 Non-H58 X6
05-2556 2005 India CipDS 17 [I] 31 [S] 16 [I/S] 0.19 [S/S] Phe464 Non-H58 X7
05-9141 2005 India CipDS 17 [I] 28 [S] 12 [I/S] 0.125 [S/S] Tyr464 Non-H58 X3
06-426 2006 India CipDS 20 [S] 25 [S] 8 [S/S] 0.125 [S/S] Tyr464 Non-H58 X3
07-6086 2007 Tunisia Pansusceptible 16 [I] 31 [S] 16 [I/S] 0.047 [S/S] WT ND ND
08-7675† 2008 India ASCSulTmpSXTCipDS 18 [I] 28 [S] 8 [S/S] 0.125 [S/S] Phe464 H58 X1
09-1986† 2008 India ASCSulTmpSXTCipDS 18 [I] 27 [S] 8 [S/S] 0.125 [S/S] Phe464 ND X1
09-0350 2009 Unknown CipDS 19 [I] 27 [S] 8 [S/S] 0.125 [S/S] Phe464 Non-H58 X5
09-2317 2009 French Guyana Pansusceptible 19 [I] 32 [S] 8 [S/S] 0.032 [S/S] Glu468 Non-H58 X4

*PFGE, pulsed-field gel electrophoresis; Nal, nalidixic acid; Cip, ciprofloxacin; WT, wild type; ND, not determined; A, ampicillin; S, streptomycin, C, chloramphenicol; Su, sulfamethoxazole; Tmp, trimethoprim; SXT, cotrimoxazole; CipDS, decreased susceptibility to ciprofloxacin. Disk diffusion test was performed and interpreted ([S], susceptible; [I], intermediate) following recommendations of antibiogram committee of the French Society for Microbiology. MICs were determined by Etest strips, and categorization was made according to the French Society for Microbiology and Clinical and Laboratory Standards Institute.
†Previously described same patient (13).

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