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Volume 17, Number 6—June 2011

Dispatch

Invasive Streptococcus pneumoniae in Children, Malawi, 2004–2006

Jennifer E. CornickComments to Author , Dean B. Everett, Caroline Broughton, Brigitte B. Denis, Daniel L. Banda, Enitan D. Carrol, and Christopher M. Parry
Author affiliations: Author affiliations: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi (J.E. Cornick, D.B. Everett, B.B. Denis, D.L. Banda, E.D. Carrol); University of Liverpool, Liverpool, UK (J.E. Cornick, D.B. Everett, C. Broughton, E.D. Carrol, C.M. Parry); University of Malawi College of Medicine, Blantyre (D.L. Banda); Angkor Hospital for Children, Siem Reap, Cambodia (C.M. Parry)

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Table 2

Antimicrobial drug susceptibilities of Streptococcus pneumoniae isolates from children at Queen Elizabeth Central Hospital, Blantyre, Malawi, 2004–2006*

Antimicrobial drug MIC, mg/L
No. (%) isolates*
Breakpoint values
Minimum Maximum MIC50 MIC90 GM S I R S I R
Benzyl penicillin
Meningitis breakpoints <0.016 0.500 <0.016 0.094 0.025 156 (90) 18 (10) <0.06 >0.12
Nonmeningitis breakpoints <0.016 0.500 <0.016 0.094 0.025 176 (100) 0 0 <2.0 4.0 >8.0
Ceftriaxone
Meningitis breakpoints <0.016 0.250 <0.016 0.064 0.025 176 (100) 0 0 <0.5 1.0 >2.0
Nonmeningitis breakpoints <0.016 0.500 <0.016 0.094 0.025 176 (100) 0 0 <1.0 2.0 >4.0
Chloramphenicol 0.380 30.000 3.000 25.000 4.660 129 (73) 47 (27) <4.0 >8.0

*MIC50, 50% MIC; MIC90, 90% MIC; GM, geometric mean; S, susceptible; I, intermediate; R, resistant; –, no intermediate resistance values for these antimicrobial drugs, according to Clinical and Laboratory Standards Institute definitions.

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