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Volume 17, Number 6—June 2011

Research

Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Ted CohenComments to Author , Megan Murray, Ibrahim Abubakar, Zibiao Zhang, Alexander Sloutsky, Fernando Arteaga, Katiuska Chalco, Molly F. Franke, and Mercedes C. Becerra
Author affiliations: Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (T. Cohen, M. Murray, Z. Zhang, M.C. Becerra); Harvard School of Public Health, Boston (T. Cohen, M. Murray); University of East Anglia, Norwich, UK (I. Abubakar); Health Protection Agency Centre for Infections, London, UK (I. Abubakar); University of Massachusetts Medical School, Boston (A. Sloutsky); Partners In Health, Boston and Lima, Peru (F. Arteaga, K. Chalco, M.F. Franke, M.C. Becerra); and Harvard Medical School, Boston (M.F. Franke, M.C. Becerra)

Main Article

Table A1

Households with potential multiple introductions of MDR TB, Lima, Peru, 1996–2004*

House ID no. Patient age, y/sex Date MIRU-VNTR pattern Spoligotype ST Lineage Drug susceptibility,
SHRECFYTKZALP†
4‡ 21/M 1997 Feb 1 2 2 2 3 3 2 4 2 2 6 1 5 3 2 3 3 3 4 2 1 2 3 + 2 736177607700171 1476 U SRRSSSSSSSXXX

22/M
1997 Jan 14
3 2 3 3 3 2 4 3 1 5 1 5 3 2 4 4 3 4 2 3 4 3 6 3
777740777760771
219
T1
SRRXSSSSSRXXX
112 19/M 2001 Nov 14 4 2 4 3 2 2 4 3 2 1 1 4 3 2 4 3 3 4 2 3 4 3 2 2 777777777760771 53 T1 RRRRRSSSRSRSS

25/M
2001 Nov 13
4 2 4 3 5 2 3 3 2 1 1 4 3 2 4 3 3 4 2 3 4 3 2 2
777777777760771
53
T1
RRRRRSSRRRRSS
126‡ 27/M 2001 May 7 2 1 4 3 3 2 4 2 2 6 1 5 3 2 1 5 2 4 1 5 3 4 8 2 777777607760771 42 LAM9 RRRRSSSRSRSSS

22/F
2001 May 2
2 1 2 3 2 1 4 3 2 7 1 5 3 2 8 4 2 4 1 4 3 1 5 2
777400007760771
1594
T1
RRRRSRSRSRSRS
192 29/F 2000 Feb 25 2 1 5 3 3 2 3 1 2 4 1 2 2 1 1 5 3 4 1 5 3 3 8 2 777777607760731 60 LAM4 RRRRSRSSSRXXX

23/F
2001 May 31
2 1 5 3 3 2 3 1 2 4 1 2 2 2 1 4 3 4 1 5 3 3 8 2
777777607760731
60
LAM4
RRRRSSSRSRXSS
361‡ 27/M 1998 May 20 3 2 3 2 3 2 5 3 2 5 1 4 3 2 2 5 3 4 1 3 4 5 4 3 700036777760771 91 X3 RRRRXXXXXRXXX

26/F
1999 Mar 1
4 2 4 3 2 2 3 3 2 1 1 5 3 2 4 3 3 4 2 3 4 3 2 2
777777777760771
53
T1
XRRSSSSSSRXXX
517‡ 66/F 2002 May 7 3 2 3 3 3 2 4 3 2 5 1 4 3 2 2 3 4 4 4 3 4 6 6 3 700036777760771 91 X3 RRRRSSSSSRSSS

30/M
2001 Nov 21
4 2 3 3 3 2 3 3 2 1 1 5 3 2 4 3 3 4 2 3 4 3 2 2
777777777760771
53
T1
RRRSSSSSSSSSS
557 24/M 2003 Apr 25 3 2 3 3 3 2 5 3 2 5 1 5 3 2 3 3 2 4 4 3 5 4 7 3 777777777720761 ND ND RRRRSSSRRSRSS

18/M
2002 Oct 9
3 2 3 3 3 2 5 3 2 5 1 5 3 2 3 3 2 4 4 3 4 5 7 3
777777777720771
50
H3
SRRRSSSRSSSSS
685‡ 19/F 2003 Apr 4 3 2 3 3 3 2 5 3 2 5 1 5 3 2 3 3 2 4 4 3 6 5 7 3 777777707720771 512 H3 SRRRSSSSSRSSS

30/M
2003 Jul 17
4 2 4 3 2 2 3 3 2 1 1 5 3 2 4 3 3 4 2 3 4 3 2 2
777777777760771
53
T1
SRRRSSSSSRSSS
960 19/F 2002 Jul 18 1 1 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 5 3 4 4 2 777737607760771 93 LAM5 RRRRSSSSSRSSS

16/M
2000 Aug 7
2 1 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 4 3 4 4 2
777737607760771
93
LAM5
RRRRSSSSSRXXX
28‡ 18/M 2001 Feb 20 2 2 4 3 2 1 4 2 2 6 1 5 3 2 2 4 3 4 1 3 3 2 7 2 777774077560771 222 T1 SRRRSSSRSRXSS
NA 2002 May 25 4 2 4 3 2 2 3 3 2 1 1 5 3 2 4 3 3 4 2 3 4 3 2 2 777777777760771 53 T1 RRRRSSSSSRSSS

20/M
2001 Aug 31
2 2 4 3 2 1 4 2 2 6 1 5 3 2 2 4 3 4 1 3 3 2 7 2
777774077560771
222
T1
SRRSSSSRSRSSS
106‡ 35/M 1997 Aug 23 2 1 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 5 3 4 4 2 777737607760771 93 LAM5 SRRRSSSSSRXXX
33/F 2000 May 5 2 2 + 3 2 1 4 3 2 6 1 4 3 2 0 4 3 4 1 3 3 2 6 2 777777607760771 42 LAM9 RRRRSRSSSRXXX

15/M
2000 Aug 29
2 2 + 3 2 1 4 3 2 6 1 4 3 2 0 4 3 4 1 3 3 2 6 2
777777607760771
42
LAM9
RRRSSSSSSRXXX
263 75/F 2002 Aug 7 3 2 3 3 3 2 5 3 2 5 1 4 3 2 2 8 2 2 1 3 4 4 6 3 700036777760771 91 X3 RRRRSSSRSRSSS
19/F 1997 Oct 25 3 2 3 3 3 2 5 3 2 5 1 4 3 2 2 5 2 2 1 3 4 4 6 3 700036777760771 91 X3 RRRRSSSRSRSXX
35/F 1996 Dec 11 3 2 3 3 3 2 5 3 2 5 1 4 3 2 2 5 2 2 1 3 4 4 6 3 700036777760771 91 X3 RRRRSSSRSRXXX
16/F 1996 Oct 17 3 2 3 3 3 2 5 3 2 5 1 4 3 2 2 5 2 2 1 3 4 4 7 3 700036777760771 91 X3 RRRRSSSRSSXXX

28/F
1996 Oct 17
3 2 3 3 3 2 5 3 2 5 1 4 3 2 2 5 2 2 1 3 4 4 6 3
700036777760771
91
X3
RRRRRRSRSRSXX
439‡ 21/M 2001 Oct 25 3 1 4 3 3 2 3 3 2 1 1 5 3 2 5 3 3 4 2 3 4 3 2 2 777777777460771 1905 T1 RRRRRRSRRRSSS

19/M
2002 Jun 17
2 2 4 3 2 1 4 3 2 6 1 5 3 2 2 4 4 4 1 3 3 2 5 2
777777407560731
1355
T2
RRRRSSSSSRSSS
645 23/M 2001 Nov 13 2 1 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 5 3 4 4 2 777737607760771 93 LAM5 SRRSSSSSSRSSS
22/F 2002 Jul 3 2 2 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 5 3 4 4 2 777737607760771 93 LAM5 SRRRSSSSSRSSS

27/F
2001 Jan 24
2 1 4 3 3 2 4 2 2 6 1 5 3 2 1 4 3 4 1 5 3 3 4 2
777737607760771
93
LAM5
SRRRSSSSSRSSS
976‡ 27/F 2002 Aug 27 4 1 4 3 2 2 3 3 2 1 1 5 3 2 4 3 3 4 2 3 4 3 2 2 777777777760771 53 T1 RRRRSSSSSRSSS

26/M
2002 Mar 30
3 2 3 3 3 2 3 3 2 5 1 4 3 2 2 5 3 4 4 3 4 7 6 3
700036777760771
91
X3
RRRRSSSSRRRSS
977‡ 19/M 2003 Feb 21 2 2 4 3 3 2 4 3 2 6 1 5 3 2 3 3 3 4 2 1 2 4 7 2 776177607660731 ND ND SRRRSSSSSRSSS
46/F NA 4 2 4 3 5 2 3 3 2 5 1 7 3 3 3 5 5 4 4 3 4 6 8 2 000000000003731 190 Beijing SRRRSSSRRRSSS
20/M 2002 Jul 5 2 2 4 3 3 2 4 3 2 6 1 5 3 2 3 3 3 4 2 1 2 3 7 2 776177607660731 ND ND RRRRSSSRSSSSS

*MDR TB, multidrug-resistant tuberculosis; ID, identification, MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; ST, shared type; ND, not determined because ST and lineage could not be assigned on the basis of spoligotype; NA, not available.
†Antimicrobial drugs tested were streptomycin (S), isoniazid (H), rifampin (R), ethambutol (E), capreomycin (C), ciprofloxacin (F), cycloserine (Y), ethionamide (T), kanamycin (K), pyrazinamide (Z), amikacin (A), levofloxacin (L), and p-amino salicylic acid (P). Susceptibility patterns: S, susceptible; R, resistant; X, no result.
‡These 10 households were ultimately categorized as probable settings of multiple MDR TB introductions for subsequent analysis.

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