Circulating Coxsackievirus A16 Identified as Recombinant Type A Human Enterovirus, China
Figure 2. Phylogenetic analysis of Changchun and Hangzhou coxsackievirus 16A (CA16) sequences. A) Bootscanning results representing selected Changchun and Hangzhou sequences. changchun104 was shown for bootscanning analysis with human enterovirus A (HEV-A) sequences and shzh00-1 as references. The results suggested changchun104 was similar to shzh00-1. The red vertical line indicates position 3,555, which corresponded to shzh00-1. B) hangzhou212, hangzhou023, and all Changchun sequences clustered with shzh00-1, shzh05-1, and GZ08, with a very high bootstrap value (100%). Another Hangzhou sequence, hangzhou114, was most likely related to CA4. ● indicates Hangzhou sequences; ■ indicates Changchun sequences, and ▲ indicates shzh00-1, shzh05-1, and GZ08. Scale bar indicates nucleotide substitutions per site. C) Map of the People’s Republic of China indicating the provinces where shzh00-1–like CA16 sequences were characterized.