Circulating Coxsackievirus A16 Identified as Recombinant Type A Human Enterovirus, China
Ke Zhao, Xue Han, Guanjun Wang, Wei Hu, Wenyan Zhang, and Xiao-Fang Yu
Author affiliations: Author affiliations: First Hospital of Jilin University, Changchun, People’s Republic of China (K. Zhao, X. Han, G. Wang, W. Hu, W. Zhang, X.-F. Yu); Johns Hopkins University, Baltimore, Maryland, USA (K. Zhao, X.-F. Yu)
Figure 2. Phylogenetic analysis of Changchun and Hangzhou coxsackievirus 16A (CA16) sequences. A) Bootscanning results representing selected Changchun and Hangzhou sequences. changchun104 was shown for bootscanning analysis with human enterovirus A (HEV-A) sequences and shzh00-1 as references. The results suggested changchun104 was similar to shzh00-1. The red vertical line indicates position 3,555, which corresponded to shzh00-1. B) hangzhou212, hangzhou023, and all Changchun sequences clustered with shzh00-1, shzh05-1, and GZ08, with a very high bootstrap value (100%). Another Hangzhou sequence, hangzhou114, was most likely related to CA4. ● indicates Hangzhou sequences; ■ indicates Changchun sequences, and ▲ indicates shzh00-1, shzh05-1, and GZ08. Scale bar indicates nucleotide substitutions per site. C) Map of the People’s Republic of China indicating the provinces where shzh00-1–like CA16 sequences were characterized.
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