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Volume 17, Number 8—August 2011

Dispatch

Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child

Alireza Eshaghi, Samir N. Patel, Alicia Sarabia, Rachel R. Higgins, Alexei Savchenko, Peter J. Stojios, Yan Li, Nathalie Bastien, David C. Alexander, Donald E. Low, and Jonathan B. GubbayComments to Author 
Author affiliations: Author affiliations: Ontario Agency for Health Protection and Promotion, Toronto, Ontario, Canada (A. Eshaghi, S.N. Patel, R.R. Higgins, D.C. Alexander, D.E. Low, J.B. Gubbay); The Credit Valley Hospital, Mississauga, Ontario, Canada (A. Sarabia); University of Toronto, Toronto (A. Savchenko, P.J. Stojios, D.C. Alexander, D.E. Low, J.B. Gubbay); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (Y. Li, N. Bastien); Mount Sinai Hospital, Toronto (D.E. Low, J.B. Gubbay); The Hospital for Sick Children, Toronto (J.B. Gubbay)

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Table 2

Susceptibility of I223R mutant and control pandemic (H1N1) 2009 strains to zanamivir in the chemiluminescent NA inhibition assay, 2010*

Virus strain
 NA mutation
 Susceptibility
OAHPP testing
NML testing
Mean IC50 ± SD, nmol
 -fold increase
 Mean IC50 ± SD, nmol
 -fold increase
A/Ontario/313762/2009 I223R 2.46 ± 0.30† 12 6.84 ± 1.3† 9
A/California/07/2009-like control Wild type 0.20 ± 0.11‡ 0.79 ± 0.45‡
Oseltamivir-resistant -control H275Y 0.20 ± 0.05§ 0.76 ± 0.35§

*NA, neuraminidase; OAHPP, Ontario Agency for Health Protection and Promotion; NML, National Microbiology Laboratoy; IC50, 50% inhibitory concentration.
†For 7 and 4 experiments done by OAHPP and NML, respectively.
‡For 15 and 1,446 experiments done by OAHPP and NML, respectively.
§For 9 and 14 experiments done by OAHPP and NML, respectively.

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