TY - JOUR AU - Johnson, Sandra AU - Ihekweazu, Chikwe AU - Hardelid, Pia AU - Raphaely, Nika AU - Hoschler, Katja AU - Bermingham, Alison AU - Abid, Muhammad AU - Pebody, Richard AU - Bickler, Graham AU - Watson, John AU - O’Moore, Éamonn T1 - Seroepidemiologic Study of Pandemic (H1N1) 2009 during Outbreak in Boarding School, England T2 - Emerging Infectious Disease journal PY - 2011 VL - 17 IS - 9 SP - 1670 SN - 1080-6059 AB - We conducted a seroepidemiologic study during an outbreak of pandemic (H1N1) 2009 in a boarding school in England. Overall, 353 (17%) of students and staff completed a questionnaire and provided a serum sample. The attack rate was 40.5% and 34.1% for self-reported acute respiratory infection (ARI). Staff were less likely to be seropositive than students 13–15 years of age (staff 20–49 years, adjusted odds ratio [AOR] 0.30; >50 years AOR 0.20). Teachers were more likely to be seropositive than other staff (AOR 7.47, 95% confidence interval [CI] 2.31–24.2). Of seropositive persons, 44.6% (95% CI 36.2%–53.3%) did not report ARI. Conversely, of 141 with ARI and 63 with influenza-like illness, 45.8% (95% CI 37.0%–54.0%) and 30.2% (95% CI 19.2%–43.0%) had negative test results, respectively. A weak association was found between seropositivity and a prophylactic dose of antiviral agents (AOR 0.55, 95% CI 0.30–0.99); prophylactic antiviral agents lowered the odds of ARI by 50%. KW - pandemic KW - influenza KW - A/H1N1 KW - pandemic (H1N1) 2009 KW - seroepidemiology KW - outbreak KW - serology KW - asymptomatic KW - prophylaxis KW - antiviral agents KW - vaccine KW - viruses KW - England KW - United Kingdom DO - 10.3201/eid1709.100761 UR - https://wwwnc.cdc.gov/eid/article/17/9/10-0761_article ER - End of Reference